Document Detail

Effects of vasodilators on peritoneal solute and fluid transport in rat peritoneal dialysis.
MedLine Citation:
PMID:  8865867     Owner:  NLM     Status:  MEDLINE    
The pharmacological manipulation by vasodilators of peritoneal solutes and fluid kinetics was investigated. Rats were dialyzed for 240 minutes with 30 mL 4.25% glucose dialysate containing dextran 70. An angiotensin-converting enzyme inhibitor (captopril), three calcium channel blockers (nicardipine, diltiazem, and verapamil), and an +/-blocker (maxisylite) were administered intraperitoneally at various concentrations. Membrane permeability to urea, glucose, and protein, actual net ultrafiltration rate (UFR), transcapillary ultrafiltration rate (TCUFR), and peritoneal net fluid absorption rate (PNFAR) were measured. All three vasodilators caused a decrease in blood pressure, which, except for moxisylite, was associated with a decrease in net UFR. Captopril and the three calcium antagonists increased PNFAR dose dependently. Captopril increased membrane permeability to small and large molecular solutes, with a consequent decrease in TCUFR. Nicardipine and verapamil increased permeability to urea and glucose but not to protein. Only the latter decreased TCUFR. Diltiazem caused no change in permeability. In conclusion, various vasodilators administered intraperitoneally affect peritoneal solute and fluid transport differently. This should, perhaps, be taken into consideration when working with continuous ambulatory peritoneal dialysis (CAPD) patients to whom antihypertensive drugs are administered in large doses.
K Kumano; M Go; H Ning; T Sakai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in peritoneal dialysis. Conference on Peritoneal Dialysis     Volume:  12     ISSN:  1197-8554     ISO Abbreviation:  Adv Perit Dial     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-30     Completed Date:  1997-01-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104803     Medline TA:  Adv Perit Dial     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Kidney Center, Kitasato University Hospital, Sagamihara, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Calcium Channel Blockers / pharmacology
Capillary Permeability / drug effects*
Captopril / pharmacology
Cell Membrane Permeability / drug effects
Dextrans / pharmacokinetics
Dialysis Solutions / pharmacokinetics*
Dose-Response Relationship, Drug
Glucose Solution, Hypertonic / pharmacokinetics
Injections, Intraperitoneal
Moxisylyte / pharmacology
Peritoneum / blood supply*
Rats, Sprague-Dawley
Vasodilator Agents / pharmacology*
Water-Electrolyte Balance / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Calcium Channel Blockers; 0/Dialysis Solutions; 0/Glucose Solution, Hypertonic; 0/Vasodilator Agents; 54-32-0/Moxisylyte; 62571-86-2/Captopril; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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