| Effects of vasodilator drugs on venous tone in conscious rats. | |
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MedLine Citation:
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PMID: 2498109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dose-response effects of vasodilator drugs, nitroglycerin, sodium nitroprusside and hydralazine, on mean arterial pressure (MAP) and mean circulatory filling pressure (MCFP), an index of body venous tone, were investigated in conscious, unrestrained, intact rats as well as in rats treated with the ganglionic blocker, hexamethonium. The effects of these drugs were compared with those of the vehicle, normal saline, in control rats. In intact rats, i.v. infusion of nitroglycerin did not alter MAP while i.v. infusions of nitroprusside or hydralazine caused dose-dependent decreases in MAP. After ganglionic blockade, all three drugs decreased MAP. In intact rats, nitroglycerin and sodium nitroprusside did not affect MCFP but hydralazine increased MCFP. After treatment with hexamethonium, all three drugs decreased MCFP. The decreases in MCFP caused by nitroglycerin and nitroprusside, but not that by hydralazine, were significantly greater than the corresponding changes in control rats. Thus, in intact rats, the direct venodilator actions of nitroprusside and nitroglycerin were masked by endogenous sympathetic tone. When sympathetic nerve activity was attenuated, both nitroprusside and nitroglycerin have venodilator effects. Hydralazine, on the other hand, had insignificant venodilator effect both in the presence and absence of sympathetic reflexes. |
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Authors:
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H M D'Oyley; R Tabrizchi; C C Pang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 162 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-06-27 Completed Date: 1989-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 337-44 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Dose-Response Relationship, Drug Heart Rate / drug effects Hexamethonium Compounds / administration & dosage, pharmacology Hydralazine / pharmacology Infusions, Intravenous Male Muscle Tonus / drug effects* Muscle, Smooth, Vascular / drug effects* Nitroglycerin / pharmacology Nitroprusside / pharmacology Rats Rats, Inbred Strains Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Hexamethonium Compounds; 0/Vasodilator Agents; 15078-28-1/Nitroprusside; 55-63-0/Nitroglycerin; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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