Document Detail

Effects of vaso-active agents on hepatic function and blood gases in patients with cirrhosis: a study of vasopressin and nitroglycerin.
MedLine Citation:
PMID:  1571496     Owner:  NLM     Status:  MEDLINE    
The effects of vaso-active agents on hepatic function and splanchnic oxygenation were studied in 17 patients with cirrhosis and portal hypertension. Eight patients received vasopressin (0.3 iu/min) and nine patients received nitroglycerin (50 micrograms/min). Both drugs caused a significant reduction in the portal venous pressure gradient. Vasopressin infusion significantly decreased intrinsic clearance of indocyanine green (-23%, P less than 0.01). This may be due to a decreased hepatic perfusion (-28%, P less than 0.01) and portal venous oxygenation (-15% in portal venous oxygen tension, P less than 0.05). In contrast, no changes in hepatic perfusion and portal venous oxygenation were observed after nitroglycerin infusion. Nitroglycerin did not decrease intrinsic clearance of indocyanine green. These results suggest that vasodilators, rather than vasoconstrictors, might be welcome in the treatment of patients with cirrhosis and portal hypertension.
T Iwao; A Toyonaga; M Sumino; K Takagi; K Oho; K Ohkubo; R Inoue; K Tanikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  7     ISSN:  0815-9319     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:    1992 Mar-Apr
Date Detail:
Created Date:  1992-06-04     Completed Date:  1992-06-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  148-53     Citation Subset:  IM    
Second Department of Medicine, Kurume University School of Medicine, Japan.
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MeSH Terms
Carbon Dioxide / blood*
Hemodynamics / drug effects
Hepatic Veins
Liver / drug effects,  physiopathology*
Liver Cirrhosis / blood,  physiopathology*
Middle Aged
Nitroglycerin / pharmacology*
Oxygen / blood*
Portal Vein
Splanchnic Circulation / drug effects
Vasopressins / pharmacology*
Reg. No./Substance:
11000-17-2/Vasopressins; 124-38-9/Carbon Dioxide; 55-63-0/Nitroglycerin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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