Document Detail


Effects of vascular perfusion on coagulation size in radiofrequency ablation of ex vivo perfused bovine livers.
MedLine Citation:
PMID:  16523026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: A standardized perfused ex vivo bovine liver model was used to evaluate the effect of organ perfusion on coagulation size and energy deposition during radiofrequency ablation (RFA) procedures. MATERIALS AND METHODS: Bovine livers were perfused in a tank after rinsing the prepared liver vessels with anticoagulants. Tyrode's solution, oxygenated and heated to 36.5 degrees C, was used as perfusion medium. A flow and pressure controlled pump regulated Portal vein circulation; a dialysis machine provided pulsatile arterial circulation. Impedance-guided radiofrequency ablations were performed with 4-cm LeVeen electrodes with and without underlying liver perfusion. Two-dimensional diameters (Dv, Dh) of each ablation area were measured after dissecting the livers. RESULTS: In 4 bovine livers weighing 8.85 +/- 0.83 kg per organ (min, 7.7 kg; max, 9.7 kg) altogether 40 RF ablations were performed. A total of 20 ablations were generated with underlying liver perfusion (group 1) and 20 ablations with no liver perfusion (group 2). In group 1, Dv was 28.4 +/- 5.3 mm, Dh 38.6 +/- 7.8 mm, and energy deposition 36.9 +/- 18.0 kJ. The 20 ablation areas generated without liver perfusion displayed statistically significant differences, with Dv being 35.7 +/- 6.5 mm (P = 0.001), Dh 49.5 +/- 9.4 mm (P = 0.001), and energy deposition 25.5 +/- 13.0 kJ (P = 0.018). CONCLUSION: The model reproduced the cooling effect of perfused tissue during RFA. The ablation areas produced under perfusion conditions had smaller diameters despite longer exposure times and higher energy deposition.
Authors:
Rudi Georg Bitsch; Markus Düx; Thomas Helmberger; Andreas Lubienski
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  41     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-07-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Affiliation:
Department of Orthopaedics, University of Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Coagulation*
Catheter Ablation* / methods
Cattle
Liver / pathology*,  surgery
Perfusion / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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