Document Detail

Effects of vascular perfusion on coagulation size in radiofrequency ablation of ex vivo perfused bovine livers.
MedLine Citation:
PMID:  16523026     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: A standardized perfused ex vivo bovine liver model was used to evaluate the effect of organ perfusion on coagulation size and energy deposition during radiofrequency ablation (RFA) procedures. MATERIALS AND METHODS: Bovine livers were perfused in a tank after rinsing the prepared liver vessels with anticoagulants. Tyrode's solution, oxygenated and heated to 36.5 degrees C, was used as perfusion medium. A flow and pressure controlled pump regulated Portal vein circulation; a dialysis machine provided pulsatile arterial circulation. Impedance-guided radiofrequency ablations were performed with 4-cm LeVeen electrodes with and without underlying liver perfusion. Two-dimensional diameters (Dv, Dh) of each ablation area were measured after dissecting the livers. RESULTS: In 4 bovine livers weighing 8.85 +/- 0.83 kg per organ (min, 7.7 kg; max, 9.7 kg) altogether 40 RF ablations were performed. A total of 20 ablations were generated with underlying liver perfusion (group 1) and 20 ablations with no liver perfusion (group 2). In group 1, Dv was 28.4 +/- 5.3 mm, Dh 38.6 +/- 7.8 mm, and energy deposition 36.9 +/- 18.0 kJ. The 20 ablation areas generated without liver perfusion displayed statistically significant differences, with Dv being 35.7 +/- 6.5 mm (P = 0.001), Dh 49.5 +/- 9.4 mm (P = 0.001), and energy deposition 25.5 +/- 13.0 kJ (P = 0.018). CONCLUSION: The model reproduced the cooling effect of perfused tissue during RFA. The ablation areas produced under perfusion conditions had smaller diameters despite longer exposure times and higher energy deposition.
Rudi Georg Bitsch; Markus Düx; Thomas Helmberger; Andreas Lubienski
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative radiology     Volume:  41     ISSN:  0020-9996     ISO Abbreviation:  Invest Radiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-07-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0045377     Medline TA:  Invest Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  422-7     Citation Subset:  IM    
Department of Orthopaedics, University of Heidelberg, Germany.
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MeSH Terms
Blood Coagulation*
Catheter Ablation* / methods
Liver / pathology*,  surgery
Perfusion / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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