| Effects of a vascular graft/natural artery compliance mismatch on pulsatile flow. | |
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MedLine Citation:
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PMID: 1564063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Attempts have been made to correlate small-diameter vascular graft patency with compliance matching between the graft and the host artery. Without knowledge about the mechanisms of failure by compliance mismatch, however, such correlations remain empirical. We have developed a flow system which mimics the flow in peripheral arteries and techniques to model a compliance mismatch in a straight elastic tube, as might occur with vascular repair. Our goal was to investigate one proposed mechanism of graft failure by compliance mismatch, that of a blood flow disturbance. Flow visualization experiments showed that, under pulsatile flow, a compliance mismatch caused trapping of 40 microns microspheres at the wall near the distal or downstream anastomosis. This suggests that the presence of a microscopic flow separation or stagnant zone in vivo may contribute to the intimal hyperplasia and thrombosis seen in failed grafts. |
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Authors:
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S F Stewart; D J Lyman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomechanics Volume: 25 ISSN: 0021-9290 ISO Abbreviation: J Biomech Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-05-15 Completed Date: 1992-05-15 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0157375 Medline TA: J Biomech Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 297-310 Citation Subset: IM |
Affiliation:
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Department of Materials Science and Engineering, University of Utah, Salt Lake City 84112. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration Anastomosis, Surgical Animals Arteries / physiology*, surgery, transplantation* Blood Flow Velocity Blood Pressure Dogs Elasticity Femoral Artery Models, Cardiovascular Pulsatile Flow Regional Blood Flow Stress, Mechanical Thrombosis / physiopathology Vascular Patency |
| Grant Support | |
ID/Acronym/Agency:
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507 RR 07092/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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