Document Detail

Effects of various bile acids and their sodium salts on development of pepsinogen-altered pyloric glands in rats.
MedLine Citation:
PMID:  1363159     Owner:  NLM     Status:  MEDLINE    
Effects of dietary bile acids and their sodium salts on the development of pepsinogen-altered pyloric glands (PAPG) were examined in male WKY/N Crj rats initially given a single dose of 160 mg/kg body weight of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) by gastric intubation. From week 3 the animals were administered basal diet containing 0.5% supplements of cholic acid (CA), deoxycholic acid (DCA), chenodeoxycholic acid (CDCA) or their sodium salts (Na-C, Na-DC and Na-CDC), or 5% ascorbic acid (ASA) or its salt (Na-AS) for 18 weeks. The concentration of DCA and Na-DC was reduced to 0.3% from week 12. At week 20, animals were killed and the numbers of immunohistochemically-demonstrated PAPG were determined. Values were significantly higher with Na-C and Na-CDC than with the corresponding parent acids, and in the Na-C case PAPG development was greater than with MNNG alone. In addition, Na-CDC itself induced the numbers of PAPG significantly. These results suggest that bile salts are possible intrinsic promoters of gastric carcinogenesis. They were without effect, however, on forestomach lesions.
Y Yoshida; M Tatematsu; K Takaba; Y Shichino; N Ito
Related Documents :
16211659 - N,n-dichlorotaurine: chemical and bactericidal properties.
24136789 - Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and...
18964769 - Ionic equilibria in neutral amphiprotic solvents of low dielectric constant: titration ...
6798099 - Development and characteristics of sucralfate.
6091079 - Comparative study of four antacids.
16266129 - Isolation and identification of a novel impurity of erythromycin a 9-oxime desosaminehy...
1887529 - Investigations of the efficacy of ascorbic acid therapy in cystinuria.
20097909 - Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid po...
8122789 - Spectrophotometric assay of eumelanin in tissue samples.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Teratogenesis, carcinogenesis, and mutagenesis     Volume:  12     ISSN:  0270-3211     ISO Abbreviation:  Teratog., Carcinog. Mutagen.     Publication Date:  1992  
Date Detail:
Created Date:  1993-03-17     Completed Date:  1993-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100917     Medline TA:  Teratog Carcinog Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  IM    
First Department of Pathology, Nagoya City University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bile Acids and Salts / administration & dosage*
Carcinoma / chemically induced*
Drug Synergism
Methylnitronitrosoguanidine / administration & dosage*
Pylorus / pathology
Rats, Inbred WKY
Stomach Neoplasms / chemically induced*
Reg. No./Substance:
0/Bile Acids and Salts; 70-25-7/Methylnitronitrosoguanidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Tumor formation and sister chromatid exchange induction by ethyl carbamate: relationships among non-...
Next Document:  The modulatory effects of tryptamine and tyramine on the S9-mediated mutagenesis of IQ and MeIQ in S...