| Effects of variations in duodenal glucose load on blood pressure, heart rate, superior mesenteric artery blood flow and plasma noradrenaline in healthy young and older subjects. | |
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MedLine Citation:
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PMID: 21942924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Postprandial hypotension leading to increased morbidity, and mortality, is an important clinical problem, particularly in the elderly and individuals with autonomic dysfunction. The magnitude of the postprandial fall in blood pressure (BP) appears to be dependent on the rate of nutrient entry into the small intestine and may be related to changes in splanchnic blood flow and sympathetic nerve activity. We aimed to determine the comparative effects of different intraduodenal (ID) glucose loads on BP, heart rate (HR), superior mesenteric artery (SMA) flow and vascular conductance and plasma noradrenaline (NA) in 'young' and 'older' subjects. Twelve 'young' (6M,6F; age 22.2±2.3yr) and twelve 'older' (6M,6F; age 68.7±1.0yr) subjects had measurements of BP, HR, SMA flow and plasma NA before, and during, ID infusions of glucose at 1, 2 or 3 kcal/min ('G1', 'G2', 'G3'), or saline ('S') for 60 minutes. In 'young' subjects, there was no change in BP during any of the four infusions. In contrast, in 'older' subjects, systolic BP fell during 'G2', and 'G3' (P<0.005 for both), but not during 'S' or 'G1'. In 'young' and 'older' subjects HR increased during 'G2' (P<0.05) and 'G3' (P<0.001), a response which was greater (P<0.05) in the young, but not during 'S' or 'G1'. The rises in SMA flow and vascular conductance in response to ID glucose were load-dependent in both 'young' and 'older' subjects (P<0.001 for all), with no difference between them. Plasma NA rose in response to 'G2' and 'G3' (P<0.05) in the young, but in 'G3' only (P<0.05) in the elderly, with no difference between them. Hence, in response to small intestinal glucose infusions at 1, 2 and 3 kcal/min 'older', but not 'young', subjects exhibit a comparable fall in BP in response to the two higher glucose loads, which may reflect an inadequate, compensatory, rise in HR, in the older subjects, but not a greater increase in SMA conductance. |
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Authors:
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Laurence G Trahair; Lora Vanis; Diana Gentilcore; Kylie Lange; Christopher K Rayner; Michael Horowitz; Karen L Jones |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-27 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: - ISSN: 1470-8736 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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