Document Detail


Effects of valeryl salicylate, a COX-1 inhibitor, on models of acute inflammation in mice.
MedLine Citation:
PMID:  12967587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of valeryl salicylate (VS), an inhibitor of cyclooxygenase-1 (COX-1), was evaluated in arachidonic acid or croton oil-induced ear oedema and carrageenan-induced paw oedema in mice. Ear oedema was induced by topical administration of arachidonic acid (2mg per ear; 20 microliters) or croton oil (1mg per ear; 20 microliters) to the inner surface of the left ear and the change in the ear's thickness was measured with a precision micrometer (Fisher, USA). VS significantly inhibited the arachidonic acid ear oedema after lh at doses of 1.5-45 micrograms per ear; however, only at the dose of 45 micrograms per ear was it able to significantly reduce the croton oil-induced oedema at 6h. Paw oedema was induced by the injection of 25 microliters of 1% carrageenan into the plantar aponeurosis of the right hind paw. The oedema was evaluated at 0.5, 1, 2, 4, 24, 48 and 72h. Previously in our experiments, we observed two peaks in paw oedema formation: one at 2h, in the early phase (0-4h), and the other, occurring at 48h after carrageenan injection, in the late phase (24-72h). The pre-treatment with VS significantly reduced the paw oedema at 2h, the same effect observed with celecoxib and indomethacin treatments. At 24h, VS did not inhibit oedema but significantly increased it mainly at 48h after carrageenan injection. These results showed that VS was pharmacologically active in these models and suggest that COX-1 may participate in the early and late phases of inflammation in the models studied.
Authors:
Jarbas M Siqueira-Junior; Rodrigo R Peters; Artur J de Brum-Fernandes; Rosa M Ribeiro-do-Valle
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  48     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-09-11     Completed Date:  2004-06-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  437-43     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Rua Ferreira Lima, 82, CEP: 88015-420, Florianópolis, -SC, Brazil. jarbasms@farmaco.ufsc.br
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Arachidonic Acid
Carrageenan
Croton Oil
Cyclooxygenase 1
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / therapeutic use*
Dose-Response Relationship, Drug
Ear, External / pathology
Edema / chemically induced,  prevention & control
Foot / pathology
Indomethacin / therapeutic use
Inflammation / drug therapy*,  pathology*
Irritants
Isoenzymes / metabolism*
Male
Membrane Proteins
Mice
Prostaglandin-Endoperoxide Synthases / metabolism*
Pyrazoles
Salicylates / therapeutic use*
Sulfonamides / therapeutic use
Chemical
Reg. No./Substance:
0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Irritants; 0/Isoenzymes; 0/Membrane Proteins; 0/Pyrazoles; 0/Salicylates; 0/Sulfonamides; 0/valerylsalicylate; 169590-42-5/celecoxib; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 8001-28-3/Croton Oil; 9000-07-1/Carrageenan; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases; EC 1.14.99.1/Ptgs1 protein, mouse

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