Document Detail

Effects of vaginal progesterone on pain and uterine contractility in patients with threatened abortion before twelve weeks of pregnancy.
MedLine Citation:
PMID:  15731312     Owner:  NLM     Status:  MEDLINE    
Fifty women with previous diagnosis of inadequate luteal phase and threatened abortion underwent a prospective, randomized, double-blind study in one medical center carried out with a parallel trial. The primary objective was to establish the effects of vaginal progesterone (Crinone 8%) in reducing both pain and uterine contractions (UCs). The gel with or without (placebo) vaginal progesterone was administered once a day since the diagnosis of threatened abortion and for 5 days. The efficacy on pain symptom amelioration was evaluated by a 5-score intensity gradation, while the UCs were evaluated by ultrasound. The secondary objective of the study was to evaluate the outcome of the pregnancies. The use of progesterone was effective both on pain relief and on the frequency of the UCs that decreased after 5 days of vaginal progesterone administration (P < 0.005). The evaluation of the ongoing pregnancy and spontaneous abortion in both study groups after 60 days showed that 4 patients of group A and 8 patients of group B miscarried (P < 0.05). In conclusion, patients with threatened abortion benefit from vaginal progesterone by a reduction of UCs and pain. The use of vaginal progesterone improved the outcome of pregnancies complicated by threatened abortion and previous diagnosis of inadequate luteal phase.
A Palagiano; C Bulletti; M C Pace; D DE Ziegler; E Cicinelli; A Izzo
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  1034     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-25     Completed Date:  2005-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  200-10     Citation Subset:  IM    
Department of Obstetrics, Gynecology, and Reproductive Sciences, Second University of Naples, 80138 Naples, Italy.
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MeSH Terms
Abortion, Threatened / drug therapy*
Administration, Intravaginal
Infertility, Female / drug therapy
Labor Pain / drug therapy*
Luteal Phase
Pregnancy Outcome
Progesterone / administration & dosage*,  analogs & derivatives*
Prospective Studies
Uterine Contraction / drug effects*
Uterus / drug effects
Reg. No./Substance:
0/Crinone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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