| Effects of vaginal progesterone administration on uterine contractility at the time of embryo transfer. | |
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MedLine Citation:
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PMID: 11384639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate whether uterine contractility at the time of embryo transfer (ET) can be reduced by early onset of luteal support with progesterone administered vaginally. DESIGN: Prospective analysis. SETTING: Assisted reproduction unit. PATIENT(S): Eighty-four women undergoing 84 GnRH-a and FSH/hCG cycles for IVF-ET were studied. INTERVENTION(S): Vaginal progesterone was randomly started on the day of oocyte retrieval (group A, n = 43) or on the evening of ET (group B, n = 41). On the day of hCG administration and just before ET, 2-minute sagittal uterine scans were obtained by ultrasound and digitized with an image analysis system for assessing uterine contraction frequency. MAIN OUTCOME MEASURE(S): Uterine contraction frequency. RESULT(S): Whereas uterine contraction frequency was similar in both groups on the day of hCG (4.6 +/- 0.3 and 4.5 +/- 0.3 contractions per minute, respectively), only women in group A showed decreased uterine contraction frequency on the day of ET (2.8 +/- 0.2 vs. 4.2 +/- 0.3 contractions per minute). CONCLUSION(S): Vaginal progesterone administration starting on the day of oocyte retrieval induced a decrease in uterine contraction frequency on the day of ET as compared with preovulatory values. Uterine relaxation before ET is likely to improve IVF-ET outcome by avoiding the displacement of embryos from the uterine cavity. |
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Authors:
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R Fanchin; C Righini; D de Ziegler; F Olivennes; N Ledée; R Frydman |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Fertility and sterility Volume: 75 ISSN: 0015-0282 ISO Abbreviation: Fertil. Steril. Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-05-31 Completed Date: 2001-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1136-40 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hôpital Antoine Béclère, Clamart, France. renato.fanchin@abc.ap-hop-paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Embryo Transfer* Estradiol / blood Female Fertilization in Vitro Follicular Phase Humans Image Processing, Computer-Assisted Infertility, Female / drug therapy, physiopathology Progesterone / administration & dosage*, blood, therapeutic use Prospective Studies Uterine Contraction / drug effects* Uterus / ultrasonography Vagina / physiopathology* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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