Document Detail

Effects of vagal pacing on food intake and body mass in pigs.
MedLine Citation:
PMID:  16261879     Owner:  NLM     Status:  MEDLINE    
In obesity patients inexpensive, non-invasive, low risk treatment remains a holy grail. The purpose of this study was to evaluate effect of long term and low frequency vagal pacing on feeding behavior in pigs. METHODS: Two groups of animals were investigated, first control with sham operation and second group with microchip (MC) on both vagal nerves placed laparoscopically. In both groups EGG was performed before and after MC implantation. Parameters of stimulation were stable (amplitude 170 mV, frequency 1 Hz, impulse duration 170 ms). RESULTS: MC group demonstrated continuous decrease in body weight gain during 8 weeks of experiment at average of 3.73 +/- 0.5 vs. 4.83 +/- 1.1 (p < 0.05). Food intake also decreased in MC group and was 16.38 +/- 1.3 vs. control 17.5 +/- 1.7 kg/w (ns). EGG recording showed decreased percent normogastria in MC group 26.66 +/- 10 vs. 76.2 +/- 16 (p < 0.05) mostly at cost of tachygastria 62.3 +/- 15 vs. 35.4 +/- 16% of the recording time. CONCLUSION: MC vagal pacing mostly decreased body weight being without significant influence on food intake causing gastric dysrhythmia.
Andrzej Matyja; Piotr J Thor; Jacek Sobocki; Janusz Laskiewicz; Jerzy Kekus; Ryszard Tuz; Józef Koczanowski; Wiesław Zaraska
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Folia medica Cracoviensia     Volume:  45     ISSN:  0015-5616     ISO Abbreviation:  Folia Med Cracov     Publication Date:  2004  
Date Detail:
Created Date:  2005-11-02     Completed Date:  2006-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374617     Medline TA:  Folia Med Cracov     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
I Katedra Chriurgii, Collegium Medicum Uniwersytetu Jagiellońskiego.
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MeSH Terms
Body Mass Index
Body Weight*
Electric Stimulation
Electric Stimulation Therapy* / instrumentation
Obesity / physiopathology*,  therapy
Vagus Nerve / physiopathology*

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