Document Detail

Effects of vagal neuromodulation and vagotomy on control of food intake and body weight in rats.
MedLine Citation:
PMID:  14726614     Owner:  NLM     Status:  MEDLINE    
Food induced neurohumoral signals are conduced to data processing brain centers mainly as vagal afferent discharge resulting in food intake regulation. The aim of this study was to evaluate effects of vagal nerve neuromodulation in control of food intake with fed-pattern microchip (MC) pacing. Experiments were performed on 60 rats divided on 5 groups: I group 0,05Hz left vagal pacing, II - pacing of both vagal nerves with MC 0,05Hz, III- left vagal MC 0,1Hz pacing, IV - pacing of both vagal nerves with MC 0,1 Hz was performed. In group V left vagal pacing was combined with right side abdominal vagotomy. Body weight and total food intake decreased by 12% and 14% (I), 26% and 30%(II), 8% and 21%(III), 14% and 30%(IV), 38% and 41%(IV), respectively (p<0.05). Effects of both vagal nerves stimulation on final body weight and food intake was significantly more effective than only single nerve MC pacing however most effective was stimulation with 0,1Hz combined with right vagotomy. We conclude that vagal stimulation reduce food intake and body weight by increasing vagal afferent signals. Our results suggest that information in vagal afferents can be modulated resulting in changes of feeding behaviour and body weight.
J Laskiewicz; G Królczyk; G Zurowski; J Sobocki; A Matyja; P J Thor
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society     Volume:  54     ISSN:  0867-5910     ISO Abbreviation:  J. Physiol. Pharmacol.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-16     Completed Date:  2004-09-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114501     Medline TA:  J Physiol Pharmacol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  603-10     Citation Subset:  IM    
Department of Pathophysiology, Jagiellonian University, Cracow, Poland.
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MeSH Terms
Afferent Pathways / physiology
Body Weight / physiology*
Eating / physiology*
Electric Stimulation / methods
Electronics, Medical
Implants, Experimental / trends
Neural Conduction / physiology
Rats, Wistar
Satiety Response / physiology
Vagus Nerve / physiology*,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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