Document Detail

Effects of uteroplacental insufficiency and reducing litter size on maternal mammary function and postnatal offspring growth.
MedLine Citation:
PMID:  18077510     Owner:  NLM     Status:  MEDLINE    
Human intrauterine growth restriction is often associated with uteroplacental insufficiency and a decline in nutrient and oxygen supply to the fetus. This study investigated the effects of uteroplacental insufficiency and intrauterine growth restriction (Restricted) or reducing litter size for normally grown pups (Reduced Litter) on maternal mammary development and function, milk composition, offspring milk intake, and their resultant effects on postnatal growth. Uteroplacental insufficiency was surgically induced by bilateral uterine vessel ligation on day 18 of gestation in the Wistar Kyoto rat. At birth, a group of sham control rats had their litter size reduced to five (Reduced Litter) to match that of the Restricted group. Cohorts of rats were terminally anesthetized on day 20 of gestation or day 6 of lactation, and a third group was studied throughout lactation. Restricted pups had a lower birth weight (by 16%) and litter size (by 36%) compared with controls, as well as reduced mammary parathyroid hormone-related protein content and milk ionic calcium concentrations associated with reduced total pup calcium. Restricted dams with lower circulating progesterone experienced premature lactogenesis, producing less milk per pup with altered composition compared with controls, further slowing growth during lactation. Reducing litter size of pups born of normal birth weight (Reduced Litter) was associated with decreased pup growth, highlighting the importance of appropriate controls. The present study demonstrates that uteroplacental insufficiency impairs mammary function, compromises milk quality and quantity, and reduces calcium transport into milk, further restraining postnatal growth.
Rachael O'Dowd; Jacqueline C Kent; Jane M Moseley; Mary E Wlodek
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-12
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  294     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-31     Completed Date:  2008-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R539-48     Citation Subset:  IM    
Department of Physiology, University of Melbourne, Melbourne, Victoria 3010, Australia.
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MeSH Terms
Animals, Suckling / growth & development*
Body Weight / physiology
Calcium / metabolism
Lactation / physiology
Litter Size / physiology*
Mammary Glands, Animal / physiology*
Milk / metabolism
Organ Size / physiology
Parathyroid Hormone-Related Protein / blood
Placental Insufficiency / physiopathology*
Prenatal Exposure Delayed Effects / physiopathology*
Progesterone / blood
Rats, Inbred WKY
Reg. No./Substance:
0/Parathyroid Hormone-Related Protein; 57-83-0/Progesterone; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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