Document Detail

Effects of the use of fibrin glue around the colonic anastomosis of the rat.
MedLine Citation:
PMID:  14605925     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study was aimed at examining whether the addition of fibrin glue to a sutured colonic anastomosis improves its healing or not. METHODS: We studied the effect of adding fibrin glue on a sutured colonic anastomosis. Thirty-six Wistar rats were randomized into two groups of 18 rats each. A sutured anastomosis was performed in all rats. Fibrin glue was applied around the anastomosis of the rats of group B. Rats were sacrificed on the eighth postoperative day. RESULTS: The rate of anastomotic leakage was found not to be significantly different between the two groups. The mean bursting pressure of the colonic anastomoses was significantly higher in group B (fibrin-treated) than in group A. CONCLUSION: Fibrin glue application around a sutured anastomosis provides a safer anastomosis which is stronger than the sutured one.
I Kanellos; I Mantzoros; I Goulimaris; E Zacharakis; A Zavitsanakis; D Betsis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Techniques in coloproctology     Volume:  7     ISSN:  1123-6337     ISO Abbreviation:  Tech Coloproctol     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-11-07     Completed Date:  2004-01-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9613614     Medline TA:  Tech Coloproctol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  82-4     Citation Subset:  IM    
Fourth Department of Surgery, Aristotle University of Thessaloniki, Greece.
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MeSH Terms
Anastomosis, Surgical / methods
Chi-Square Distribution
Colectomy / methods*
Disease Models, Animal
Fibrin Tissue Adhesive / pharmacology*
Random Allocation
Rats, Wistar
Reference Values
Sensitivity and Specificity
Statistics, Nonparametric
Tensile Strength
Reg. No./Substance:
0/Fibrin Tissue Adhesive

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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