Document Detail


Effects of ursolic acid, betulin and sulfur-containing compounds on mucin release from airway goblet cells.
MedLine Citation:
PMID:  15643543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated whether ursolic acid, betulin and 2 kinds of sulfur-containing compounds--NAC and MESNA--affect mucin release from airway goblet cells and compared the possible activities of these agents with the inhibitory action on mucin release by PLL and the stimulatory action by ATP. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled using 3H-glucosamine for 24 h and chased for 30 min in the presence of varying concentrations of each agent to assess the effects on 3H-mucin release. The results were as follows: ursolic acid, betulin, MESNA and NAC increased mucin release (40-50 % above control) at the highest concentrations (10(-5) M-10(-3) M). We conclude that ursolic acid and betulin can stimulate mucin release by directly acting on airway mucin-secreting cells and suggest that these agents be further investigated for the possible use as mucoregulators in the treatment of chronic airway diseases.
Authors:
Choong Jae Lee; Jeong Ho Seok; Gang Min Hur; Jae Heun Lee; Ji Sun Park; In Chan Seol; Yun Hee Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Planta medica     Volume:  70     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-03-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1119-22     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Korea. LCJ123@cnu.ac.kr
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / administration & dosage,  pharmacology,  therapeutic use
Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage,  pharmacology*,  therapeutic use
Betula*
Cornus*
Cricetinae
Dose-Response Relationship, Drug
Goblet Cells / drug effects,  metabolism
Male
Mesna / administration & dosage,  pharmacology,  therapeutic use
Mesocricetus
Mucins / biosynthesis*
Phytotherapy*
Trachea / cytology,  drug effects
Triterpenes / administration & dosage,  pharmacology,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Mucins; 0/Triterpenes; 19767-45-4/Mesna; 473-98-3/betulin; 616-91-1/Acetylcysteine; 77-52-1/ursolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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