Document Detail


Effects of urinary trypsin inhibitor in patients at risk for premature labor with a bulging fetal membrane.
MedLine Citation:
PMID:  11844908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the effect of urinary trypsin inhibitor (UTI) in patients at risk for premature labor with bulging membrane. METHODS: Patients who had developed a bulging membrane from 22 to 27 weeks and 6 days of gestation were studied. These cases were divided into two types based on the severity: those with a moderately developed bulging membrane like a 'dome' (dome type), and those with a membrane prolapsed into the vagina, resulting in an 'hourglass' shape (hourglass type). We compared the outcomes of treatment with or without UTI (UTI group versus non-UTI group) in each type. Gestational age at delivery, birth weight, prolongation time from admission to delivery, and neonatal mortality rate were examined in each group. RESULTS: A total of 43 patients with a bulging membrane were analyzed. In 21 patients with the dome type, gestational age at delivery (the UTI group versus the non-UTI group; 30.4 +/- 5.0 versus 26.4 +/- 1.9 weeks, p < 0.05), birth weight (1,436.8 +/- 708.3 versus 882.8 +/- 261.6 g, p < 0.05) and neonatal mortality rate (0/13 versus 3/8, p < 0.05) were all significantly improved by the use of UTI. On the other hand, in 22 patients with the hourglass type, there was no significant difference between the UTI group and the non-UTI group. The overall prevalence of histological chorioamnionitis was 60%. CONCLUSION: These results suggest that UTI therapy is very effective in patients at risk for premature labor with a moderately developed bulging membrane during the second trimester.
Authors:
Yoshio Matsuda; Naoki Yunohara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  17     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2002 Mar-Apr
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Affiliation:
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan. ymatsuda@obgy.twmu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Chorioamnionitis / complications
Extraembryonic Membranes / pathology*
Female
Gestational Age
Glycoproteins / therapeutic use*
Humans
Infant Mortality
Infant, Newborn
Infant, Premature
Obstetric Labor, Premature / prevention & control*
Pregnancy
Pregnancy Complications*
Prolapse
Risk Factors
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glycoproteins; 80449-32-7/urinastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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