Document Detail

Effects of ureteral obstruction on the toxicity of cephalosporins in the rabbit kidney.
MedLine Citation:
PMID:  7069237     Owner:  NLM     Status:  MEDLINE    
The nephrotoxicity of the cephalosporin antibiotics is closely related to their secretory transport into the proximal tubular cell at the antiluminal (blood) site. The present report describes the effects of transient ureteral obstruction, which increases intracellular concentrations of secreted organic anions, on the cortical uptake and the proximal tubular toxicity of several cephalosporins given in mildly toxic doses. Unilateral obstruction for 1-2 hr increased the cytotoxicity of cephaloglycin and cefaclor, both of which are rapidly secreted across the tubular cell, but not of cephaloridine, which undergoes minimal secretion. Bilateral obstruction significantly increased the toxicity of cefaclor, which is rapidly secreted, but not of cefazolin, which is slowly secreted. Finally, there was a further augmentation of the effects of obstruction on the toxicity of cefaclor by a minimally toxic pretreatment regimen of neomycin. Studies of cortical antibiotic concentrations support the conclusion that the effects on toxicity are largely the result of the increased intracellular accumulation that results from obstruction.
P L Wang; D J Prime; C Y Hsu; B M Tune
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  145     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-06-24     Completed Date:  1982-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  574-81     Citation Subset:  AIM; IM    
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MeSH Terms
Cefaclor / toxicity
Cefazolin / toxicity
Cephaloglycin / toxicity
Cephaloridine / toxicity
Cephalosporins / metabolism,  toxicity*
Kidney Cortex / metabolism*
Kidney Tubules, Proximal / drug effects*
Neomycin / pharmacology
Reg. No./Substance:
0/Cephalosporins; 1404-04-2/Neomycin; 25953-19-9/Cefazolin; 3577-01-3/Cephaloglycin; 50-59-9/Cephaloridine; 53994-73-3/Cefaclor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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