Document Detail


Effects of unilateral cervical vagotomy on antral endocrine cells in mouse.
MedLine Citation:
PMID:  10425538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was carried out to investigate the effect of unilateral cervical vagotomy on the antral endocrine cells in mouse. Fifty-four mice were randomly divided into three groups, 18 in each, for left or right cervical vagotomy, or sham operation as controls. The animals were sacrificed 2, 4, and 8 weeks after the operation, respectively. Chromogranin-, gastrin/CCK-, serotonin-, and somatostatin-cells were detected by immunohistochemistry and quantitated by computerised image analysis. The results showed that the number of chromogranin-cells was decreased in both left and right vagotomized mice after 4 weeks and remained at the same level after 8 weeks. The numbers of gastrin-, serotonin- and somatostatin-cells did not change after right vagotomy. However, the numbers of gastrin- and somatostatin-cells were decreased after left vagotomy, whereas no change was found in serotonin-cells. Endocrine cells with vacuolated cytoplasm and pyknotic nuclei were also observed during the course of time. The alteration in the antral endocrine cells observed in this study seemed to be dynamic and depended on the observation time after the operation as well as the denervated branches of the vagus nerve. This may explain, at least partially the contradictory results obtained earlier by different investigators.
Authors:
B F Qian; M el-Salhy; A Danielsson; A Shalaby; H Axelsson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Histology and histopathology     Volume:  14     ISSN:  0213-3911     ISO Abbreviation:  Histol. Histopathol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-10-06     Completed Date:  1999-10-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8609357     Medline TA:  Histol Histopathol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  705-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, University Hospital, Umeå University, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Cervix Uteri / innervation*
Chromogranin A
Chromogranins / analysis
Enteroendocrine Cells*
Female
Gastrins / analysis
Image Processing, Computer-Assisted
Immunoenzyme Techniques
Male
Mice
Pyloric Antrum / innervation
Rabbits
Serotonin / analysis
Somatostatin / analysis
Stomach / chemistry,  cytology*,  innervation
Vagotomy
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Chromogranin A; 0/Chromogranins; 0/Gastrins; 50-67-9/Serotonin; 51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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