Document Detail


Effects of unaccustomed and accustomed exercise on the immune response in runners.
MedLine Citation:
PMID:  17019295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To test the hypothesis that long-term immunological response may be different after accustomed concentric and unaccustomed eccentric exercise in endurance-trained men. METHODS: Fourteen highly endurance-trained male runners performed two bouts of high-intensity exercise with at least 2-wk intervals between bouts. Concentric exercise consisted of a 60-min level run with a targeted heart rate of 80% VO2 peak. Eccentric exercise was conducted lying on a specially designed exercise rack, eliciting eccentric action of the musculus quadriceps femoris. Blood samples were taken before and 1, 6, 24, 72, and 144 h after exercise to determine creatine kinase (CK), C-reactive protein (CRP), and interleukin-6 (IL-6). Lymphocyte subset distribution was assessed using flow cytometry. RESULTS: We found a significant (P < 0.05) increase of CD4 (eccentric: 17%; concentric: 20%), CD3+/CD4+ (16 vs 19%), CD25+ (45 vs 29%), CD25+/CD4+ (27 vs 50%), HLA-DR+ (20 vs 15%), HLA-DR+/CD4+ (16 vs 67%), and CD19+/CD45+ (52 vs 103%) positive lymphocytes 1 h after both exercise bouts. However, eccentric exercise resulted in a significantly higher and longer (6 h) increase of CD25+/CD4+ and HLA-DR+/CD8+ lymphocytes and a peak increase of CK at 72 h. IL-6 and CRP increased only after concentric exercise within the first 24 h. Both exercises resulted in a decrease of monocyte activation (LFA-1: CD18+/CD11a+) after 6 h, with an increase for the eccentric exercise part after 24 h (P < 0.05). CONCLUSION: Accustomed concentric exercise mainly induced an acute-phase response, with increased CRP, IL-6, and activation of CD4 lymphocyte subsets. Unaccustomed eccentric exercise provided a delayed increase in CK and activation of monocytes and CD4+ and CD8+ subsets. Therefore, the immunological reaction depends not only on the type of contraction but also on the adaptation to the exercise.
Authors:
Stephan Sorichter; Maria Martin; Peter Julius; Ansgar Schwirtz; Martin Huonker; Werner Luttmann; Stephan Walterspacher; Aloys Berg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  38     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-04     Completed Date:  2006-12-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1739-45     Citation Subset:  IM; S    
Affiliation:
Department of Pneumology, University Hospital Freiburg, Germany. sorichter@med1.ukl.uni-freiburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
C-Reactive Protein
CD4 Lymphocyte Count
Creatine Kinase
Exercise / physiology*
Humans
Interleukin-6
Leukocytes
Lymphocytes
Male
Muscle Contraction / physiology*
Muscle, Skeletal / immunology*,  physiology
Physical Endurance / immunology*
Prospective Studies
Running / physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Interleukin-6; 9007-41-4/C-Reactive Protein; EC 2.7.3.2/Creatine Kinase

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