| Effects of unaccustomed and accustomed exercise on the immune response in runners. | |
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MedLine Citation:
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PMID: 17019295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To test the hypothesis that long-term immunological response may be different after accustomed concentric and unaccustomed eccentric exercise in endurance-trained men. METHODS: Fourteen highly endurance-trained male runners performed two bouts of high-intensity exercise with at least 2-wk intervals between bouts. Concentric exercise consisted of a 60-min level run with a targeted heart rate of 80% VO2 peak. Eccentric exercise was conducted lying on a specially designed exercise rack, eliciting eccentric action of the musculus quadriceps femoris. Blood samples were taken before and 1, 6, 24, 72, and 144 h after exercise to determine creatine kinase (CK), C-reactive protein (CRP), and interleukin-6 (IL-6). Lymphocyte subset distribution was assessed using flow cytometry. RESULTS: We found a significant (P < 0.05) increase of CD4 (eccentric: 17%; concentric: 20%), CD3+/CD4+ (16 vs 19%), CD25+ (45 vs 29%), CD25+/CD4+ (27 vs 50%), HLA-DR+ (20 vs 15%), HLA-DR+/CD4+ (16 vs 67%), and CD19+/CD45+ (52 vs 103%) positive lymphocytes 1 h after both exercise bouts. However, eccentric exercise resulted in a significantly higher and longer (6 h) increase of CD25+/CD4+ and HLA-DR+/CD8+ lymphocytes and a peak increase of CK at 72 h. IL-6 and CRP increased only after concentric exercise within the first 24 h. Both exercises resulted in a decrease of monocyte activation (LFA-1: CD18+/CD11a+) after 6 h, with an increase for the eccentric exercise part after 24 h (P < 0.05). CONCLUSION: Accustomed concentric exercise mainly induced an acute-phase response, with increased CRP, IL-6, and activation of CD4 lymphocyte subsets. Unaccustomed eccentric exercise provided a delayed increase in CK and activation of monocytes and CD4+ and CD8+ subsets. Therefore, the immunological reaction depends not only on the type of contraction but also on the adaptation to the exercise. |
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Authors:
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Stephan Sorichter; Maria Martin; Peter Julius; Ansgar Schwirtz; Martin Huonker; Werner Luttmann; Stephan Walterspacher; Aloys Berg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 38 ISSN: 0195-9131 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-04 Completed Date: 2006-12-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 1739-45 Citation Subset: IM; S |
Affiliation:
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Department of Pneumology, University Hospital Freiburg, Germany. sorichter@med1.ukl.uni-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult C-Reactive Protein CD4 Lymphocyte Count Creatine Kinase Exercise / physiology* Humans Interleukin-6 Leukocytes Lymphocytes Male Muscle Contraction / physiology* Muscle, Skeletal / immunology*, physiology Physical Endurance / immunology* Prospective Studies Running / physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 9007-41-4/C-Reactive Protein; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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