Document Detail

Effects of ultraviolet radiation on the immune system in humans.
MedLine Citation:
PMID:  2687907     Owner:  NLM     Status:  MEDLINE    
In experimental animals, exposure to UV-B radiation produces selective alterations of immune function which are mainly in the form of suppression of normal immune responses. This immune suppression is important in the development of nonmelanoma skin cancer, may influence the development and course of infectious disease and possibly protects against autoimmune reactions. The evidence that this form of immune suppression occurs in humans is less compelling and very incomplete. The wavelengths of radiation most affected by a depletion of the stratospheric ozone layer are those known to be most immunosuppressive in animals and it is likely that such depletion will increase any suppressive effect of sunlight on immunity in humans. In addition to establishing whether or not UV-B radiation can cause suppression of immune function in humans, studies are required to determine if melanin can provide protection against such suppression, the role of this suppression in the pathogenesis of skin cancer, the development of infectious disease and vaccine effectiveness, and the capacity for humans to develop adaptive, protective mechanisms which may limit damage from continued exposure to UV-B radiation.
W L Morison
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  50     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-01-25     Completed Date:  1990-01-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  515-24     Citation Subset:  IM    
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MeSH Terms
Dermatitis, Contact / prevention & control
Immune System / radiation effects*
Infection / etiology
Langerhans Cells / radiation effects
Lymphocytes / radiation effects
Neoplasms, Radiation-Induced / etiology
Skin Neoplasms / etiology
Ultraviolet Rays / adverse effects*

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