| Effects of ultrasound on placental transfer during the last third of gestation in the rat. | |
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MedLine Citation:
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PMID: 2339475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of ultrasound on placental transfer in the rat has been measured in vivo. At 15, 18, 21 and 22 days of gestation one uterine horn of each anaesthetized rat was exposed, after laparatomy, to ultrasound. The control horn was effectively shielded. Radio-labelled tracers were then injected into the maternal circulation via a jugular vein cannula and fetuses removed simultaneously from both experimental and control horns at times predetermined to ensure minimal backflux from fetus to mother. Samples of maternal plasma were also taken at suitable intervals. The radioactive content of fetuses and plasma were measured and a unidirectional materno-fetal clearance value (Kmf) for each fetus calculated. It was shown that in rats whose body temperature was accurately maintained at 37 degrees C, ultrasound at the level used in the present study had no effect on placental clearance. However, in rats whose body temperature was allowed to fall to 32 degrees C, a 3 min exposure to 1.1 MHz continuous wave ultrasound at 1 W cm-2 caused a significant (p less than 0.001) decrease in the placental clearance of 22Na (by 55%) and 51Cr-EDTA (by 45%) in rats at 15 days of gestation. These effects showed no dose response and were not observed in rats at any of the other stages of gestation which we investigated. However, in rats at 21 days of gestation the clearance of 45Ca2+ was significantly (p less than 0.01) reduced (by 30%) by a similar exposure to ultrasound. It is concluded that although an interesting biological effect of ultrasound at low body temperatures has been observed, it has little relevance for the normal use of ultrasound in obstetrics. |
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Authors:
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D E Atkinson; C P Sibley; A R Williams |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ultrasonics Volume: 28 ISSN: 0041-624X ISO Abbreviation: Ultrasonics Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-18 Completed Date: 1990-06-18 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0050452 Medline TA: Ultrasonics Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 171-4 Citation Subset: IM |
Affiliation:
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Department of Child Health, University of Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / pharmacokinetics* Calcium Radioisotopes / diagnostic use Embryonic and Fetal Development Female Gestational Age* Maternal-Fetal Exchange Placenta / metabolism* Pregnancy Rats Rats, Inbred Strains Sodium / pharmacokinetics* Sodium Radioisotopes / diagnostic use Temperature Ultrasonics* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Radioisotopes; 0/Sodium Radioisotopes; 7440-23-5/Sodium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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