Document Detail

Effects of ultrasound contrast agents on Doppler tissue velocity estimation.
MedLine Citation:
PMID:  16455419     Owner:  NLM     Status:  MEDLINE    
The combination of Doppler tissue imaging and myocardial contrast echocardiography has the potential to provide information about motion and perfusion of the myocardium in a single examination. The purpose of this study was to establish how the presence of ultrasound contrast agent (UCA) affects measurements of Doppler tissue velocities in vivo and in vitro. We performed echocardiography in 12 patients with ischemic heart disease before and immediately after a slow intravenous infusion of the UCA Optison, using color Doppler tissue imaging to examine the effect of contrast agents in vivo. The myocardial peak systolic velocities and their integrals were analyzed in digitally stored cineloops before and after contrast administration. To distinguish between methodologic and physiologic factors affecting the measurement of tissue velocity in vitro, experiments with a rotating disk and a flow cone phantom were also carried out for the 3 contrast agents: Optison, Sonovue, and Sonazoid. In vivo results show that the values for peak systolic velocity increased by about 10% during contrast infusion, from mean 5.2 +/- 1.8 to 5.7 +/- 2.3 cm/s (P = .02, 95% confidence interval 2%-16%). The increase in myocardial peak systolic velocities was verified in experimental models in which the UCA increased the estimated mean velocity in the order of 5% to 20% for the motion interval of 5 to 7 cm/s, corresponding to the myocardial velocities studied in vivo. The response was similar for all 3 contrast agents and was not affected by moderate variations in concentration of the agent. We have shown that the presence UCA will affect Doppler tissue measurements in vivo and in vitro. The observed bias is presumed to be an effect of harmonic signal contribution from rupturing contrast agent microbubbles and does not indicate biologic or physiologic effects.
Marcus Ressner; Lars-Ake Brodin; Tomas Jansson; Lars Hoff; Per Ask; Birgitta Janerot-Sjoberg
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Publication Detail:
Type:  Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  19     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-03     Completed Date:  2006-04-26     Revised Date:  2011-12-12    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  154-64     Citation Subset:  IM    
Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
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MeSH Terms
Aged, 80 and over
Albumins / diagnostic use*
Contrast Media
Echocardiography / methods*
Ferric Compounds / diagnostic use*
Fluorocarbons / diagnostic use*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods
Iron / diagnostic use*
Middle Aged
Myocardial Infarction
Myocardial Ischemia / complications,  ultrasonography*
Oxides / diagnostic use*
Phospholipids / diagnostic use*
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume*
Sulfur Hexafluoride / diagnostic use*
Ventricular Dysfunction, Left / etiology,  ultrasonography*
Reg. No./Substance:
0/Albumins; 0/Contrast Media; 0/FS 069; 0/Ferric Compounds; 0/Fluorocarbons; 0/Oxides; 0/Phospholipids; 0/Sonazoid; 0/contrast agent BR1; 2551-62-4/Sulfur Hexafluoride; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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