Document Detail

Effects of a typical and an atypical antipsychotic on the disruption of prepulse inhibition caused by corticotropin-releasing factor and by rat strain.
MedLine Citation:
PMID:  16187833     Owner:  NLM     Status:  MEDLINE    
Male Wistar-Kyoto (WKY) and Brown Norway (BN) rats (11-12 weeks, n = 184) received an injection of saline, haloperidol, or clozapine, followed by an intracerebroventricular infusion of saline or corticotropin-releasing factor (CRF). Rats were tested for prepulse inhibition (PPI) of the acoustic startle response. BN rats showed less PPI than WKY rats, and neither antipsychotic alone enhanced PPI. In WKY rats, both haloperidol and clozapine attenuated the CRF-induced decrease in PPI. In CRF-treated BN rats, clozapine-enhanced PPI. A clozapine-induced decrease in startle amplitude was seen in CRF-treated BN rats but not in CRF-treated WKY rats. Although the disruption of PPI caused by exogenous CRF administration can be reversed by acute antipsychotic treatment, baseline PPI is not altered.
Lisa H Conti; Jennifer E Costill; Sean Flynn; Jane E Tayler
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  119     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-09-28     Completed Date:  2006-01-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1052-60     Citation Subset:  IM    
Copyright Information:
(c) 2005 APA
Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA.
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MeSH Terms
Acoustic Stimulation / methods
Analysis of Variance
Antipsychotic Agents / pharmacology*
Behavior, Animal / drug effects
Clozapine / pharmacology
Corticotropin-Releasing Hormone / pharmacology*
Dose-Response Relationship, Drug
Dose-Response Relationship, Radiation
Drug Interactions
Haloperidol / pharmacology
Hormones / pharmacology*
Injections, Intraventricular / methods
Neural Inhibition / drug effects*
Rats, Inbred BN
Rats, Inbred WKY
Startle Reaction / drug effects*
Grant Support
Reg. No./Substance:
0/Antipsychotic Agents; 0/Hormones; 52-86-8/Haloperidol; 5786-21-0/Clozapine; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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