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Effects of two-months Nigella sativa supplementation on cardiac hemodynamics and adrenergic responsiveness.
MedLine Citation:
PMID:  19534369     Owner:  NLM     Status:  In-Process    
OBJECTIVE: To study the effects of two, months Nigella sativa (N. sativa) oral supplementation to normal rats on cardiac haemodynamics in vivo, the ionotropic and chronotropic properties of the isolated hearts in vitro, and the cardiac responsiveness to progressive adrenergic stimulation by isoproterenol. METHODS: The cardiac workload, after 2 months of N. sativa oral supplementation to normal adult rats, was assessed in vivo by measuring the cardiac pressure-rate product (mean arterial blood pressure multiplied by heart rate). Cardiac performance in vitro was evaluated by calculating the tension-rate product (developed peak tension multiplied by heart rate). The cardiac inotropic and chronotropic adrenergic responsiveness of N. sativa supplemented rats were evaluated in a Langendorff heart model upon graded infusion of the beta-adrenergic agonist isoproterenol. RESULTS: The isolated hearts of Nigella-treated rats maintained their normal cardiac adrenergic responsiveness, with a selective enhancement of both the tension-rate product and the inotropic reserve. In contrast, the in vivo cardiac pressure-rate product in N. sativa supplemented rats was not significantly different from the control group. CONCLUSION: The demonstrated favourable results of N. sativa supplementation on the intrinsic cardiac contractile properties without evidence of an increased cardiac work load or energy consumption in vivo makes N. sativa an attractive inotropic agent with an economic haemodynamic profile. Further research is recommended to explore the usefulness of N. sativa in cardiovascular disorders associated with systolic dysfunction.
Mohammad Taha Al-Hariri; Talay Yar; Abdullah Omar Bamosa; Mohammad Nabil El-Bahai
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  59     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  363-8     Citation Subset:  IM    
Department of Physiology, College of Medicine, King Faisal University, Dammam 31451, Kingdom of Saudi Arabia.
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