| Effects of two-month consumption of 30 g a day of soy protein isolate or skimmed curd protein on blood lipid concentration in Russian adults with hyperlipidemia. | |
| | |
MedLine Citation:
|
PMID: 20086319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recently the American Heart Association has reported that favorable effects of soy protein on blood lipids were characteristic only for high amounts of soy protein and not observed for an intake less than 30 g/d. However, the period of the studies with the smaller amount was 4-6 wk and we thought a longer study was necessary for the conclusion. The death rate by heart disease is very high in Russia; therefore, we have done this study in Russian subjects with hyperlipidemia. Prior to the study we tried to find a favorable method for subjects to take 30 g protein a day from soybean protein isolate (SPI) or skimmed curd protein (SMP) and decided to use Russian style cookies. Thirty subjects with hyperlipidemia were recruited; however, due to the 5-mo long study 28 of them (19 females and 9 males aged 50+/-2 y) could complete the trial. They were randomly assigned to two groups and were given either cookie for 2 mo separated by a month-long washout interval in a cross-over design. Fasting blood samples were drawn before and after the dietary treatments. Fasting blood samples at 1 mo were also measured as a health check and to observe the trends of the blood parameters in the middle of the study period. Serum samples were used for the lipid and other biochemical measurements. Every month for 3 non-consecutive days, energy and nutrient intakes were assessed and physical activity was estimated by pedometer. With the consumption of SPI for 2 mo, concentrations of total-cholesterol changed from 280+/-7 to 263+/-8 mg/dL (-6.5%, p=0.0099), HDL-cholesterol from 57.4+/-2.5 to 62.6+/-2.9 mg/dL (+9%, p=0.0047), non-HDL-cholesterol (total-cholesterol-HDL-cholesterol) from 223+/-7 to 201+/-8 mg/dL (-11%, p=0.0023) and triglycerides from 204+/-23 to 173+/- 19 mg/dL (-18%, p=0.022). There were no significant changes with SMP (p>0.05). Thus, administration of 30 g SPI a day for 2 mo confirmed its favorable effects on serum lipids in Russians with hyperlipidemia. |
| | |
Authors:
|
Eugene A Borodin; Iraida G Menshikova; Vladimir A Dorovskikh; Natalya A Feoktistova; Mikhail A Shtarberg; Takashi Yamamoto; Kiyoharu Takamatsu; Hiroyuki Mori; Shigeru Yamamoto |
Related Documents
:
|
20658749 - Changes in lipids and lipoprotein particle concentrations after interruption of antiret... 10428319 - Hormone replacement therapy and lipid-lipoprotein concentrations. 3081149 - High density lipoprotein cholesterol is not a major risk factor for ischaemic heart dis... 9189839 - Male and female cord blood lipoprotein profile differences throughout the term-period. 17215179 - Effects of phytosterols in diacylglycerol as part of diet therapy on hyperlipidemia in ... 18639879 - Association between lipid profile and circulating concentrations of estrogens in young ... 6090279 - Comparison between the bacterial and oligosaccharide content of ileostomy effluent in s... 10328359 - Effect of protein intake during gestation and lactation on the lactational performance ... 20172549 - Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of nutritional science and vitaminology Volume: 55 ISSN: 1881-7742 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2010-01-20 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: Japan |
Other Details:
|
Languages: eng Pagination: 492-7 Citation Subset: IM |
Affiliation:
|
Amur State Medical Academy, Blagoveshchensk, Russian Federation. borodin@amur.ru |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antilipemic Agents
/
administration & dosage*,
pharmacology Cholesterol / blood* Cross-Over Studies Dietary Proteins / administration & dosage*, pharmacology Female Humans Hyperlipidemias / diet therapy* Male Middle Aged Milk Proteins Phytotherapy Plant Preparations / administration & dosage*, pharmacology Russia Soybean Proteins / administration & dosage*, pharmacology Time Factors Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
|
0/Antilipemic Agents; 0/Dietary Proteins; 0/Milk Proteins; 0/Plant Preparations; 0/Soybean Proteins; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dissociation between PGC-1alpha and GLUT-4 expression in skeletal muscle of rats fed a high-fat diet...
Next Document: Exposure to dams' low-fat high-carbohydrate diet during pregnancy and lactation establishes a prefer...