Document Detail

Effects of two medicinal plants Psidium guajava L. (Myrtaceae) and Diospyros mespiliformis L. (Ebenaceae) leaf extracts on rat skeletal muscle cells in primary culture.
MedLine Citation:
PMID:  16365927     Owner:  NLM     Status:  MEDLINE    
Crude decoction, aqueous and ethanolic extracts of two medicinal plants (Psidium guajava and Diospyros mespiliformis), widely used in the central plateau of Burkina Faso to treat many diseases were evaluated for their antagonistic effects on caffeine induced calcium release from sarcoplasmic reticulum of rat skeletal muscle cells. These different extracts showed a decrease of caffeine induced calcium release in a dose dependent manner. Comparison of the results showed that Psidium guajava leaf extracts are more active than extracts of Diospyros mespiliformis and that crude decoctions show better inhibitory activity. The observed results could explain their use as antihypertensive and antidiarrhoeal agents in traditional medicine, by inhibiting intracellular calcium release.
R G Belemtougri; B Constantin; C Cognard; G Raymond; L Sawadogo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of Zhejiang University. Science. B     Volume:  7     ISSN:  1673-1581     ISO Abbreviation:  J Zhejiang Univ Sci B     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-20     Completed Date:  2006-02-01     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  101236535     Medline TA:  J Zhejiang Univ Sci B     Country:  China    
Other Details:
Languages:  eng     Pagination:  56-63     Citation Subset:  IM    
Laboratory of Physiological Animal, University of Ouagadougou BP 7021, Burkina Faso.
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MeSH Terms
Calcium / metabolism*
Cells, Cultured
Dose-Response Relationship, Drug
Ebenaceae / chemistry*
Muscle Fibers, Skeletal / drug effects*,  metabolism*
Plant Extracts / administration & dosage*
Plant Leaves / chemistry*
Plants, Medicinal / chemistry*
Psidium / chemistry*
Reg. No./Substance:
0/Plant Extracts; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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