Document Detail


Effects of two glucose ingestion rates on substrate utilization during moderate-intensity shivering.
MedLine Citation:
PMID:  19779734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the importance of food consumption to survive in the cold is well established, most shivering studies have focused on fuel selection in fasting subjects. Therefore, the aim of the present study was to provide the first estimates of exogenous glucose as well as liver and muscle glycogen oxidation rates of non-cold acclimatized men (n = 6) ingesting glucose in trace amounts (Control; C), and at rates of 400 mg min(-1) (Low Glucose; LG), and 800 mg min(-1) (High Glucose; HG) during moderate-intensity shivering (~3 times resting metabolic rate or ~20% VO(2max)) using indirect calorimetry and stable isotope methodologies. Exogenous glucose oxidation peaked at ~200 mg min(-1) at the lowest glucose ingestion rate (~400 mg min(-1)). In addition, glucose ingestion increased the contribution of plasma glucose to total heat production by ~50% but did not change the role played by muscle glycogen (~27% of heat production for control condition and ~23-28% for LG and HG). Instead, the contribution of liver-derived glucose to total heat production was reduced by 40-60% in LG and HG, respectively. In conclusion, glucose ingestion even at low rates contributes a significant proportion of total heat production during moderate intensity shivering and reduces the utilization of liver-derived glucose but not muscle glycogen.
Authors:
Denis P Blondin; Isabelle D?pault; Pascal Imbeault; Fran?ois P?ronnet; Marie-Andr?e Imbeault; Fran?ois Haman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-25
Journal Detail:
Title:  European journal of applied physiology     Volume:  108     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  289-300     Citation Subset:  IM    
Affiliation:
Faculty of Health Sciences, School of Human Kinetics, University of Ottawa, 125 University St., Ottawa, ON, K1N 6N5, Canada.
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MeSH Terms
Descriptor/Qualifier:
Blood Glucose / metabolism
Glucose / metabolism*
Glycogen / metabolism
Humans
Male
Oxidation-Reduction
Shivering / physiology*
Temperature
Young Adult
Chemical
Reg. No./Substance:
0/Blood Glucose; 50-99-7/Glucose; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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