Document Detail

Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans.
MedLine Citation:
PMID:  15090626     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effects of two different conjugated linoleic acid (CLA) isomers at two different intakes on body composition in overweight humans. RESEARCH METHODS AND PROCEDURES: Eighty-one middle-aged, overweight, healthy men and women participated in this bicentric, placebo-controlled, double-blind, randomized study. For 6 weeks (run-in period), all subjects consumed daily a drinkable dairy product containing 3 g of high oleic acid sunflower oil. Volunteers were then randomized over five groups receiving daily either 3 g of high oleic acid sunflower oil, 1.5 g of cis-9,trans-11 (c9t11) CLA, 3 g of c9t11 CLA, 1.5 g of trans-10,cis-12 (t10c12) CLA, or 3 g of t10c12 CLA administrated as triacylglycerol in a drinkable dairy product for 18 weeks. Percentage body fat mass and fat and lean body mass were assessed at the end of the run-in and experimental periods by DXA. Dietary intake was also recorded. RESULTS: Body fat mass changes averaged 0.1 +/- 0.9 kg (mean +/- SD) in the placebo group and -0.3 +/- 1.4, -0.8 +/- 2.1, 0.0 +/- 2.3, and -0.9 +/- 1.7 kg in the 1.5-g c9t11, 3-g c9t11, 1.5-g t10c12, and 3-g t10c12 groups, respectively. Changes among the groups were not significantly different (p = 0.444). Also, lean body mass and dietary intake were not significantly different among the treatments. DISCUSSION: A daily consumption of a drinkable dairy product containing up to 3 g of CLA isomers for 18 weeks had no statistically significant effect on body composition in overweight, middle-aged men and women.
Corinne Malpuech-Brugère; Wilhelmine P H G Verboeket-van de Venne; Ronald P Mensink; Marie-Agnès Arnal; Béatrice Morio; Marion Brandolini; Asgeir Saebo; Taous S Lassel; Jean Michel Chardigny; Jean Louis Sébédio; Bernard Beaufrère
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity research     Volume:  12     ISSN:  1071-7323     ISO Abbreviation:  Obes. Res.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9305691     Medline TA:  Obes Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  591-8     Citation Subset:  IM    
Unité du Métabolisme Protéino-Energétique, Université d'Auvergne/Institut National de la Recherche Agronomique, Centre de Recherche en Nutrition Humaine Auvergne, Clermont Ferrand, France.
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MeSH Terms
Adipose Tissue
Body Composition / drug effects*
Body Mass Index
Body Weight*
Dairy Products
Dietary Fats, Unsaturated / administration & dosage*
Double-Blind Method
Linoleic Acids, Conjugated / administration & dosage*
Middle Aged
Oleic Acid / administration & dosage
Plant Oils / administration & dosage
Triglycerides / administration & dosage
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Linoleic Acids, Conjugated; 0/Placebos; 0/Plant Oils; 0/Triglycerides; 112-80-1/Oleic Acid; 8001-21-6/sunflower seed oil

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