| Effects of two basidiomycete species on interleukin 1 and interleukin 2 production by macrophage and T cell lines. | |
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MedLine Citation:
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PMID: 19913939 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two basidiomycete species, Lentinus edodes mycelia (LEM) and Cordyceps sinensis (CS) were examined for induction of cytokines in murine macrophage cell line R309 (R309) and T cell line LBRM-33 1A5 (1A5). When lipopolysaccharide (LPS)-activated R309 were exposed to the extracts of basidiomycetes, R309 induced significant levels of interleukin 1 (IL-1). Interleukin 2 (IL-2) induction was recognized in 1A5 cultures in the presence of IL-1 and phytohemagglutinin (PHA). However, no enhancement of IL-2 production by these basidiomycetes was discerned in 1A5 cultures with IL-1 and PHA, i.e., direct action of basidiomycetes was not found on IL-2 production of 1A5. PHA-stimulated 1A5 exposed to basidiomycetes induced IL-2 without IL-1 when co-cultured with LPS-activated R309 as a source of IL-1. Effects of basidiomycetes on IL-2 production in 1A5 seemed to be caused through their action on macrophages. The induction of IL-2, Th1 type cytokine in T lymphocyte, is a significant finding since basidiomycetes, taken as a dietary supplement for immuno-suppressed patients, especially cancer patients, would be helpful in improving their immune activity against cancer. |
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Authors:
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Takashi Kawanishi; Yurika Ikeda-Dantsuji; Ariaki Nagayama |
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Publication Detail:
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Type: Journal Article Date: 2009-11-13 |
Journal Detail:
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Title: Immunobiology Volume: 215 ISSN: 1878-3279 ISO Abbreviation: Immunobiology Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-04 Completed Date: 2010-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002742 Medline TA: Immunobiology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 516-20 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Microbiology and Immunology, Fukuoka University School of Medicine, Jonan-ku, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Allergy and Immunology Animals Cell Line Cordyceps / immunology* Dietary Supplements Interleukin-1 / secretion* Interleukin-2 / secretion* Lipopolysaccharides / immunology, metabolism Macrophages / immunology, metabolism*, microbiology, pathology Mice Mice, Inbred C3H Phytohemagglutinins / immunology, metabolism Shiitake Mushrooms / immunology* T-Lymphocytes / immunology, metabolism*, microbiology, pathology Th1 Cells / immunology |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Interleukin-2; 0/Lipopolysaccharides; 0/Phytohemagglutinins |
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