Document Detail


Effects of tumors on the daily mitotic activity of mouse pars intermedia.
MedLine Citation:
PMID:  15774317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have investigated the effects of EA21a and EA34 mammary carcinomas on daily PI cell proliferation in mice. Animals were divided into groups grafted with either EA34 or EA21a carcinomas (and a non-grafted control group). They were all injected intraperitoneally with 2 microg colchicine per g of body weight 4 h before sacrifice and the number of mitoses per 1000 nuclei was calculated. The mitotic index (MI) of pars-intermedia epithelial cells in control animals showed significant temporal variations. However, the MI from mice grafted with EA34 or EA21a carcinomas showed no such variation. There was no difference between the daily MIs of controls and tumor grafted groups. The absence of a 24 h mitotic activity curve in both EA21a and EA34 tumor-bearing animals demonstrates a lower level of synchronization of cells entering mitosis.
Authors:
Jose Miguel Surur; Vicente Alberto Catalano; Mirta Alicia Flamini; Claudio Gustavo Barbeito
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-21
Journal Detail:
Title:  Cell biology international     Volume:  29     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-18     Completed Date:  2005-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  173-5     Citation Subset:  IM    
Affiliation:
Institute of Biology, Embryology and Histology, School of Medicine, National University of La Plata (Unlp) 1900, La Plata, Buenos Aires, Argentina.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carcinoma / pathology*
Cell Proliferation
Female
Male
Mammary Neoplasms, Experimental / pathology*
Mice
Mice, Inbred C3H
Mitosis
Pituitary Gland / cytology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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