Document Detail

Effects of tryptophane on SHRSP offspring growth.
MedLine Citation:
PMID:  1773528     Owner:  NLM     Status:  MEDLINE    
The effects of tryptophane on growth and hypertension of offspring obtained from mothers given L-tryptophane prior to mating: In the tryptophane group, body weights were heavier and blood pressures were higher than in the control group. Stroke lesion incidence rates were also much higher in the tryptophane group. At 20 weeks of age, brain enzyme activities were lower and serotonin content was higher in the tryptophane group in comparison with the control. These results suggest that dietary tryptophane may affect precocious maturation and as well as affect elevation in blood pressures due to brain serotonin turnover.
H Ito; H Shiokawa; M Torii; T Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  13     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-02     Completed Date:  1992-03-02     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  971-9     Citation Subset:  IM    
Department of Pathology, Kinki University School of Medicine, Osaka, Japan.
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MeSH Terms
Blood Pressure / physiology*
Body Weight / physiology*
Brain / enzymology,  metabolism
Cerebrovascular Disorders / etiology*,  genetics
Diet / adverse effects*
Disease Susceptibility
Hypertension / etiology*,  genetics
Maternal-Fetal Exchange / physiology*
Rats, Inbred SHR
Serotonin / metabolism
Tryptophan / adverse effects*
Reg. No./Substance:
50-67-9/Serotonin; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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