Document Detail

Effects of tropisetron, a 5-HT3 receptor antagonist, on proximal gastric motor and sensory function in nonulcer dyspepsia.
MedLine Citation:
PMID:  10095156     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Visceral hypersensitivity is claimed to be involved in the pathogenesis of nonulcer dyspepsia (NUD). In a double-blind crossover study, we evaluated the effects of tropisetron, a 5-HT3 receptor antagonist, on gastric accommodation, reflex relaxation, and sensitivity in NUD patients. METHODS: Eight patients and 10 healthy controls received placebo or 5 mg tropisetron on separate days. On each day, gastric accommodation and relaxation were investigated using a gastric barostat. The perception during gastric distension and relaxation was scored by a verbal perception score. RESULTS: Under both medications, gastric accommodation and postprandial gastric reflex relaxation were not impaired in the NUD patients. The visceral perception was increased in the NUD patients and not substantially influenced by tropisetron. CONCLUSIONS: Tropisetron does not influence gastric accommodation, reflex relaxation, or gastric sensitivity in NUD patients and healthy controls.
S Klatt; W Böck; J Rentschler; K Beckh; G Adler
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Digestion     Volume:  60     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  IM    
Department of Internal Medicine I, University of Ulm, Germany.
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MeSH Terms
Analysis of Variance
Cross-Over Studies
Double-Blind Method
Dyspepsia / physiopathology*
Enteric Nervous System / drug effects
Indoles / pharmacology*
Middle Aged
Reflex / drug effects
Sensory Thresholds
Serotonin Antagonists / pharmacology*
Statistics, Nonparametric
Stomach / drug effects*,  innervation,  physiopathology
Reg. No./Substance:
0/Indoles; 0/Serotonin Antagonists; 89565-68-4/tropisetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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