| Effects of tropisetron, a 5-HT3 receptor antagonist, on proximal gastric motor and sensory function in nonulcer dyspepsia. | |
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MedLine Citation:
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PMID: 10095156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Visceral hypersensitivity is claimed to be involved in the pathogenesis of nonulcer dyspepsia (NUD). In a double-blind crossover study, we evaluated the effects of tropisetron, a 5-HT3 receptor antagonist, on gastric accommodation, reflex relaxation, and sensitivity in NUD patients. METHODS: Eight patients and 10 healthy controls received placebo or 5 mg tropisetron on separate days. On each day, gastric accommodation and relaxation were investigated using a gastric barostat. The perception during gastric distension and relaxation was scored by a verbal perception score. RESULTS: Under both medications, gastric accommodation and postprandial gastric reflex relaxation were not impaired in the NUD patients. The visceral perception was increased in the NUD patients and not substantially influenced by tropisetron. CONCLUSIONS: Tropisetron does not influence gastric accommodation, reflex relaxation, or gastric sensitivity in NUD patients and healthy controls. |
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Authors:
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S Klatt; W Böck; J Rentschler; K Beckh; G Adler |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Digestion Volume: 60 ISSN: 0012-2823 ISO Abbreviation: Digestion Publication Date: 1999 Mar-Apr |
Date Detail:
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Created Date: 1999-07-08 Completed Date: 1999-07-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0150472 Medline TA: Digestion Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 147-52 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine I, University of Ulm, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Cross-Over Studies Double-Blind Method Dyspepsia / physiopathology* Enteric Nervous System / drug effects Female Humans Indoles / pharmacology* Male Middle Aged Perception Pressure Reflex / drug effects Sensory Thresholds Serotonin Antagonists / pharmacology* Statistics, Nonparametric Stomach / drug effects*, innervation, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Indoles; 0/Serotonin Antagonists; 89565-68-4/tropisetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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