| Effects of tromethamine and sodium bicarbonate buffers during cardiac resuscitation. | |
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MedLine Citation:
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PMID: 2851015 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects on cardiac resuscitability of iso-osmolal solutions of tris-hydroxymethyl-aminomethane (tromethamine), sodium bicarbonate (NaHCO3) and sodium chloride placebo were compared in 30 domestic pigs using a well-established model of electrically induced cardiac arrest and resuscitation. We hypothesized that a carbon dioxide (CO2) consuming buffer like tromethamine would reduce and sodium bicarbonate would increase the respiratory acidosis of mixed venous blood, which had recently been demonstrated in our laboratory, Tromethamine did decrease and sodium bicarbonate did increase both arterial and mixed venous CO2 during cardiopulmonary resuscitation (CPR). Both concentrations of end-tidal CO2 and coronary venous PCO2 were significantly lower after tromethamine than after bicarbonate. However, tromethamine produced an unexpected vasodilator effect with reduction of mean aortic and coronary perfusion pressures to levels that are known to reduce resuscitability and survival independently of its buffer action. Neither resuscitability nor survival was altered by bicarbonate therapy in comparison with sodium chloride placebo. |
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Authors:
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M von Planta; C Gudipati; M H Weil; L J Kraus; E C Rackow |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: 28 ISSN: 0091-2700 ISO Abbreviation: J Clin Pharmacol Publication Date: 1988 Jul |
Date Detail:
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Created Date: 1989-03-07 Completed Date: 1989-03-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 594-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Health Sciences, Chicago Medical School, North Chicago, Illinois 60064. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects Animals Bicarbonates / therapeutic use* Blood Gas Analysis Carbon Dioxide / blood Cardiac Output / drug effects Hemodynamics / drug effects Lactates / blood Resuscitation* Sodium / therapeutic use* Sodium Bicarbonate Swine Tromethamine / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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1 R01 HL39148-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bicarbonates; 0/Lactates; 124-38-9/Carbon Dioxide; 144-55-8/Sodium Bicarbonate; 7440-23-5/Sodium; 77-86-1/Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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