| Effects of trimetazidine on submaximal exercise test in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 14696632 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It was demonstrated that the novel metabolic agent, trimetazidine, could lessen the incidence and severity of angina, whether used in monotherapy or combination. Although the animal studies demonstrated that trimetazidine reduces myocardial infarct size anf improves recovery of mechanic function after ischemia, little is known on the potential benefits of trimetazidine in patients with myocardial infarction (AMI). The aim of this study was to evaluate the efficacy of trimetazidine on AMI by sub-maximal exercise test. METHODS: A double-blind crossover trimetazidine versus placebo trial was carried out in 44 patients with AMI. Patients with randomly allotted into trimetazidine (23 patients) or placebo (21 patients) for 5 days and underwent an initial sub-maximal exercise test. Exercise tests according to the modified Bruce protocol were performed. Exercise end points included completion of stage II or 75% of maximum predicted heart rate whichever came first. An average 12-lead ECG was obtained at rest, every minute during exercise, at the onset of anginal symptoms, at the onset of 1-mm ST segment depression, at peak exercise and every 2-minute during recovery. After the initial exercise tests, study groups resumed the drugs in the opposite order for 4 to 5 days and underwent a second sub-maximal exercise test. RESULTS: Exercise induced ST segment depression was noted in 17 patients (38.6%) receiving placebo. However, exercise induced ST-segment depression was observed in 8 patients (18.1%) taking TMZ. Positive exercise test results were significantly higher on placebo group than TMZ group (p=0.018). Additionally, trimetazidine prolonged the time to 1-mm ST-segment depression (6.1 +/-0.5 vs 4.9 +/-0.4, P< 0.031) and exercise duration (7.2+/-0.9 vs 5.8 +/-0.9, p<0.025). CONCLUSION: Trimetazidine therapy improves the exercise capacity and reduces evidence ischemia derived from sub-maximal post-infarction exercise testing. |
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Authors:
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Niyazi Güler; Beyhan Eryonucu; Ahmet Günes; Unal Güntekin; Mustafa Tuncer; Hanefi Ozbek |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy Volume: 17 ISSN: 0920-3206 ISO Abbreviation: Cardiovasc Drugs Ther Publication Date: 2003 Jul |
Date Detail:
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Created Date: 2003-12-29 Completed Date: 2004-05-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8712220 Medline TA: Cardiovasc Drugs Ther Country: United States |
Other Details:
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Languages: eng Pagination: 371-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Medical Faculty, Yüzüncü Ytl University, Van, Turkey. niyaziguler@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Over Studies Double-Blind Method Exercise Test / drug effects* Female Humans Male Middle Aged Myocardial Infarction / drug therapy* Trimetazidine / therapeutic use* Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 5011-34-7/Trimetazidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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