Document Detail

Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease.
MedLine Citation:
PMID:  9781975     Owner:  NLM     Status:  MEDLINE    
We studied 15 patients with chronic coronary artery disease (13 men aged 62 +/- 8 years) undergoing dobutamine (5 to 40 microg/kg/min) echocardiography at the end of two 15-day treatment periods with placebo and trimetazidine (20 mg 3 times daily) given in random order, according to a double-blind, crossover design. Results show that trimetazidine improves resting left ventricular function and reduces the severity of dobutamine-induced ischemic myocardial dysfunction.
C Lu; P Dabrowski; G Fragasso; S L Chierchia
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  82     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-11-06     Completed Date:  1998-11-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-901     Citation Subset:  AIM; IM    
Istituto Scientifico H. San Raffaele, Milan, Italy.
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MeSH Terms
Administration, Oral
Coronary Disease / complications,  physiopathology*,  ultrasonography
Cross-Over Studies
Dobutamine / diagnostic use
Drug Administration Schedule
Middle Aged
Trimetazidine / administration & dosage,  therapeutic use*
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventricular Dysfunction, Left / drug therapy*,  etiology,  ultrasonography
Reg. No./Substance:
0/Vasodilator Agents; 34368-04-2/Dobutamine; 5011-34-7/Trimetazidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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