Document Detail

Effects of triiodothyronine-induced hypermetabolism on factor 8 and fibrinogen in man.
MedLine Citation:
PMID:  5304832     Owner:  NLM     Status:  MEDLINE    
Triiodothyronine (liothyronine sodium) (400-500 mug/day for 14 days) was given to six normal subjects. Factor VIII (antihemophilic globulin) activity increased from 109 to 167% (P < 0.05); fibrinogen increased from 344 to 581 mg/100 ml (P < 0.01). To test whether the increases in factor VIII activity and fibrinogen were mediated by beta adrenergic receptors, propranolol (20 mg every 6 hr) was given orally to four other normal subjects in addition to triiodothyronine for 14 days. Factor VIII increased from 100 to 161%; fibrinogen increased from 374 to 564% (P < 0.01). Factor VIII activity did not change in a severe classical hemophiliac made hypermetabolic with triiodothyronine, but it increased from 39 to 82% in a patient with von Willebrand's disease. Triiodothyronine-induced hypermetabolism increased the incorporation of selenomethionine-(75)Se into plasma fibrinogen. These results suggest that the increases in clotting factor activity during triiodothyronine-induced hypermetabolism reflect an effect of increased protein synthesis rather than enhanced stimulation of beta adrenergic receptors.
J C Hoak; W R Wilson; E D Warner; E O Theilen; G L Fry; F L Benoit
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  48     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1969 Apr 
Date Detail:
Created Date:  1969-05-01     Completed Date:  1969-05-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  768-74     Citation Subset:  AIM; IM    
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MeSH Terms
Basal Metabolism / drug effects*
Epinephrine / pharmacology
Factor VIII / analysis,  metabolism*
Fibrinogen / analysis,  metabolism*
Hemophilia A / blood
Hyperthyroidism / blood
Methionine / blood
Propranolol / pharmacology
Sensory Receptor Cells / drug effects*
Thyroxine / pharmacology
Triiodothyronine / pharmacology*
von Willebrand Diseases / blood
Reg. No./Substance:
51-43-4/Epinephrine; 525-66-6/Propranolol; 63-68-3/Methionine; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7782-49-2/Selenium; 9001-27-8/Factor VIII; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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