Document Detail

Effects of tricyclic antidepressants on cardiovascular responses to norepinephrine and phenylephrine during pregnancy.
MedLine Citation:
PMID:  686086     Owner:  NLM     Status:  MEDLINE    
The effects of imipramine and amitriptyline on the responses of the uteroplacental vasculature to norepinephrine and phenylephrine were investigated in the pregnant ewe. Experiments were performed on conscious animals in which electromagnetic flow transducers were chronically implanted on the uterine arteries. Administered alone, the tricyclic antidepressants had no effect on mean arterial pressure (MAP) or estimated uteroplacental vascular conductance (UPVCe). Following intravenous infusion of either imipramine (1 mg. per kilogram) or amitriptyline (2.5 mg. per kilogram), the pressor response to norepinephrine (1 microgram per kilogram) and the duration of that response were significantly increased (p less than 0.05). In addition, both the duration of the norepinephrine-produced decrease in uteroplacental blood flow (UPBF) and the amplitude of the decrease in UPVCe were enhanced. In contrast, responses to phenylephrine (2.5 microgram per kilogram) were unaffected by prior administration of either imipramine or amitriptyline. Of additional interest were findings suggesting differential sensitivities to alpha-agonists of the uteroplacental compared with other vascular beds. These observations bring attention to the possibility of interactions between endogenous or exogenous norepinephrine and the tricyclic antidepressants and suggest that the possibly unique sensitivities of the uteroplacental bed should be considered when prescribing drugs during pregnancy.
B D Mason; G R Van Petten
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  131     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1978 Aug 
Date Detail:
Created Date:  1978-10-25     Completed Date:  1978-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  868-71     Citation Subset:  AIM; IM    
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MeSH Terms
Amitriptyline / pharmacology
Antidepressive Agents, Tricyclic / pharmacology*
Blood Pressure / drug effects
Imipramine / pharmacology
Norepinephrine / pharmacology*
Phenylephrine / pharmacology*
Placenta / blood supply*
Pregnancy, Animal*
Regional Blood Flow / drug effects
Uterus / blood supply*
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 50-48-6/Amitriptyline; 50-49-7/Imipramine; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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