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Effects of triazolodiazepine on the production of interleukin-6 from murine spleen cells and rabbit synovial cells in vitro.
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MedLine Citation:
PMID:  18475629     Owner:  NLM     Status:  In-Data-Review    
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates the immune response, acute phase anaphylactic reaction, and haematopoiesis. Lipopolysaccharide (6-24 mug/ml) significantly induced IL-6 release from murine spleen cells. In cultured rabbit synovial cells interleukin-1 (IL-1, 1-10 U/ml) induced IL-6 production in a concentration-dependent manner. Triazolodiazepine (Tri) is a hetrazepine platelet-activating factor antagonist. In this study we found that Tri (0.1-10 mumol/l) exerted strong inhibitory effects on LPS stimulated IL-6 production in murine spleen cells. Kinetic studies showed that the inhibition of IL-6 release was time-independent. In rabbit synovial cells Tri also reduced IL-6 release induced by IL-1 and tumour necrosis factor. Inhibition of cytokine production by Tri may partially explain its wide and strong anti-inflammatory effects.
D W Ju; Q Y Zheng; X T Cao; Q H Zheng; X J Guan; H B Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mediators of inflammation     Volume:  4     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  1995  
Date Detail:
Created Date:  2008-05-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  United States    
Other Details:
Languages:  eng     Pagination:  130-2     Citation Subset:  -    
Department of Immunology School of Basic Medicine Second Military Medical University Shanghai 200433 China.
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Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
ISSN: 1466-1861
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 1995 Hindawi Publishing Corporation.
open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Print publication date: Month: 3 Year: 1995
Volume: 4 Issue: 2
First Page: 130 Last Page: 132
ID: 2365624
PubMed Id: 18475629
Publisher Item Identifier: S0962935195000226
DOI: 10.1155/S0962935195000226

Effects of triazolodiazepine on the production of interleukin-6 from murine spleen cells and rabbit synovial cells in vitro
Dian-Wen Ju1
Qin-Yue Zheng2
Xue-Tao Cao1
Qing-Hua Zheng1
Xiao-Jun Guan1
Hong-Bin Wang2
1Department of ImmunologySchool of Basic MedicineSecond Military Medical UniversityShanghai200433China
2Department of PharmacologySchool of PharmacySecond Military Medical UniversityShanghai200433China

Article Categories:
  • Research Article

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