| Effects of treatment with testosterone alone or in combination with estrogen on insulin sensitivity in postmenopausal women. | |
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MedLine Citation:
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PMID: 16750207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Little is known about metabolic effects of testosterone treatment in postmenopausal women. The aim of the study was to compare the treatment effects of testosterone, estrogen, and testosterone plus estrogen on insulin sensitivities, body compositions, and lipid profiles in healthy postmenopausal women. DESIGN: An open, randomized clinical study with parallel group comparison. SETTING: Women's health clinical research unit at a university hospital. PATIENT(S): Sixty-three naturally postmenopausal women participated in the study. INTERVENTION(S): The participants were randomly assigned to 3 months of treatment with testosterone undecanoate (40 mg every second day), estradiol valerate (2 mg daily), or the combination of both. MAIN OUTCOME MEASURE(S): Insulin sensitivity assessed by euglycemic hyperinsulinemic clamp, body composition, and serum lipids. RESULT(S): Insulin-induced glucose disposal was reduced by approximately 20% after treatment with testosterone alone, and after the combined treatment, but not by estrogen alone. Body weight, but not total body fat, increased significantly by about 1 kg in all groups. Lean body mass was significantly increased in the group of combined treatment and tended to be increased by testosterone alone. High-density lipoprotein (HDL)-cholesterol decreased significantly by testosterone treatment. In contrast, HDL-cholesterol increased, whereas low-density lipoprotein (LDL)-cholesterol and lipoprotein-(a) [Lp(a)] decreased with estradiol treatment. CONCLUSION(S): We conclude that 3 months of treatment with testosterone undecanoate in postmenopausal women induces insulin resistance and an adverse serum lipid profile but may increase lean body mass. |
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Authors:
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Hong Zang; Kjell Carlström; Peter Arner; Angelica Lindén Hirschberg |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-06-05 |
Journal Detail:
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Title: Fertility and sterility Volume: 86 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-04 Completed Date: 2006-08-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 136-44 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Karolinska University Hospital, Stockholm, Sweden. hzang@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Composition / drug effects, physiology Drug Combinations Estrogens / administration & dosage* Female Hormone Replacement Therapy / methods* Humans Insulin / blood* Insulin Resistance / physiology* Middle Aged Postmenopause / blood*, drug effects* Testosterone / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Estrogens; 11061-68-0/Insulin; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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