Document Detail


Effects of treatment with oxandrolone for 4 years on the frequency of severe arithmetic learning disability in girls with Turner syndrome.
MedLine Citation:
PMID:  19643440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To study androgen treatment effects on arithmetic performance in girls with Turner syndrome. STUDY DESIGN: Forty-four girls, ages 10 to 14 years at baseline, completed 4 years of treatment with oxandrolone (Ox) or placebo (Pl). All received growth hormone and estrogen replacement therapy. We assessed the number of girls with severe learning disability (LD, standard score <or=5(th) percentile) on measures of academic arithmetic and reading achievement (WRAT-3, arithmetic and reading), given yearly, and the WIAT numerical operations (NOS) and reading subtests, given at year 4. RESULTS: On the WRAT-3 arithmetic, the frequency of severe arithmetic LD was similar in the Ox and Pl groups at baseline and at years 1 and 2. At years 3 and 4, fewer girls in the Ox than Pl group had a severe arithmetic LD (year 4: 0/22 vs 5/21, P = .02). On the WIAT NOS (year 4), fewer girls in the Ox than Pl groups had a severe arithmetic LD (3/21 vs 8/20, P = .09). WIAT NOS error analysis suggested that the improved performance in the Ox group was associated with better performance on multiplication and division (P < .01). The frequency of severe LD for the WRAT-3 reading was similar for the Ox and Pl groups (all years) and for the WIAT reading subtest (year 4). CONCLUSIONS: Androgen treatment for 4 years in girls with Turner syndrome resulted in a small decrease in frequency of severe arithmetic LD, with no effect on reading LD.
Authors:
Judith L Ross; Michele M M Mazzocco; Harvey Kushner; Karen Kowal; Gordon B Cutler; David Roeltgen
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2009-07-29
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2009-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  714-20     Citation Subset:  AIM; IM    
Affiliation:
Thomas Jefferson University, Department of Pediatrics, Philadelphia, PA 19107, USA. Judith.Ross@mail.tju.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Androgens / therapeutic use*
Child
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Educational Measurement
Female
Humans
Learning Disorders / diagnosis,  drug therapy*,  etiology
Mathematics*
Oxandrolone / therapeutic use*
Probability
Reading
Reference Values
Risk Assessment
Severity of Illness Index
Time Factors
Treatment Outcome
Turner Syndrome / complications,  diagnosis,  drug therapy*
Grant Support
ID/Acronym/Agency:
NS32531/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Androgens; 53-39-4/Oxandrolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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