| Effects of treatment with oxandrolone for 4 years on the frequency of severe arithmetic learning disability in girls with Turner syndrome. | |
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MedLine Citation:
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PMID: 19643440 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study androgen treatment effects on arithmetic performance in girls with Turner syndrome. STUDY DESIGN: Forty-four girls, ages 10 to 14 years at baseline, completed 4 years of treatment with oxandrolone (Ox) or placebo (Pl). All received growth hormone and estrogen replacement therapy. We assessed the number of girls with severe learning disability (LD, standard score <or=5(th) percentile) on measures of academic arithmetic and reading achievement (WRAT-3, arithmetic and reading), given yearly, and the WIAT numerical operations (NOS) and reading subtests, given at year 4. RESULTS: On the WRAT-3 arithmetic, the frequency of severe arithmetic LD was similar in the Ox and Pl groups at baseline and at years 1 and 2. At years 3 and 4, fewer girls in the Ox than Pl group had a severe arithmetic LD (year 4: 0/22 vs 5/21, P = .02). On the WIAT NOS (year 4), fewer girls in the Ox than Pl groups had a severe arithmetic LD (3/21 vs 8/20, P = .09). WIAT NOS error analysis suggested that the improved performance in the Ox group was associated with better performance on multiplication and division (P < .01). The frequency of severe LD for the WRAT-3 reading was similar for the Ox and Pl groups (all years) and for the WIAT reading subtest (year 4). CONCLUSIONS: Androgen treatment for 4 years in girls with Turner syndrome resulted in a small decrease in frequency of severe arithmetic LD, with no effect on reading LD. |
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Authors:
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Judith L Ross; Michele M M Mazzocco; Harvey Kushner; Karen Kowal; Gordon B Cutler; David Roeltgen |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2009-07-29 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 155 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-20 Completed Date: 2009-12-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 714-20 Citation Subset: AIM; IM |
Affiliation:
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Thomas Jefferson University, Department of Pediatrics, Philadelphia, PA 19107, USA. Judith.Ross@mail.tju.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Androgens / therapeutic use* Child Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Educational Measurement Female Humans Learning Disorders / diagnosis, drug therapy*, etiology Mathematics* Oxandrolone / therapeutic use* Probability Reading Reference Values Risk Assessment Severity of Illness Index Time Factors Treatment Outcome Turner Syndrome / complications, diagnosis, drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
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NS32531/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Androgens; 53-39-4/Oxandrolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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