Document Detail

Effects of treatment with Pluronic F-68 during continuous venous air embolism in swine.
MedLine Citation:
PMID:  8471956     Owner:  NLM     Status:  MEDLINE    
Treatment with the surface-active agent Pluronic F-68, shown to modulate the hemodynamic effects of venous air emboli (VAE) in dogs, may be useful for treatment of VAE in divers. We report on the effects of injections of Pluronic F-68 on responses to continuous air infusion in swine. Pretreatment made no significant difference in any hemodynamic or ventilatory variables, but the rise of pulmonary vascular resistance caused by air infusion was greater in surfactant-treated animals; this was also evident after a second treatment during the air infusion. The small effect of surfactant treatment in our study on swine contrasts the effects reported previously in dogs, and could be due to species-specific differences in lung physiology-anatomy, or due to difference in experimental design. We speculate that the minor changes we observed were caused by deeper penetration of the bubbles into the pulmonary arterial tree after surfactant treatment.
B M Jenssen; A Vik; A O Brubakk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc     Volume:  20     ISSN:  1066-2936     ISO Abbreviation:  Undersea Hyperb Med     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-17     Completed Date:  1993-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9312954     Medline TA:  Undersea Hyperb Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-26     Citation Subset:  IM; S    
Foundation for Scientific and Industrial Research, Norwegian Institute of Technology (SINTEF UNIMED), University of Trondheim.
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MeSH Terms
Blood Pressure / drug effects
Carbon Dioxide / metabolism
Decompression Sickness / complications*
Embolism, Air / drug therapy*,  etiology,  physiopathology
Oxygen / metabolism
Partial Pressure
Poloxalene / therapeutic use*
Pulmonary Artery / drug effects*,  physiology
Pulmonary Veins / drug effects*,  physiology
Random Allocation
Vascular Resistance / drug effects*
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9003-11-6/Poloxalene
Comment In:
Undersea Hyperb Med. 1993 Dec;20(4):383-4   [PMID:  8135943 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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