Document Detail


Effects and treatment of inflammatory bowel disease during pregnancy.
MedLine Citation:
PMID:  18625819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
QUESTION: I have several patients with inflammatory bowel disease (IBD) who are pregnant or planning pregnancies. What information can I give them regarding the possible effects of IBD on pregnancy and the medications used to treat IBD during pregnancy?
ANSWER: Women with IBD appear to be at increased risk of giving birth prematurely, having low-birth-weight infants, and having cesarean sections. Neither 5-aminosalicylic acid nor sulfasalazine has been found to increase the rate of major malformations, fetal mortality, or morbidity. There is conflicting evidence regarding the use of corticosteroids and azathioprine and 6-mercaptopurine. There are limited data on the use of infliximab during pregnancy, although no pattern of defects or complications has been reported to date.
Authors:
Harvinder Brar; Adrienne Einarson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  54     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-15     Completed Date:  2008-09-18     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  981-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
6-Mercaptopurine / adverse effects,  therapeutic use
Abnormalities, Drug-Induced / prevention & control
Adrenal Cortex Hormones / adverse effects,  therapeutic use
Adult
Aminosalicylic Acids / adverse effects,  therapeutic use
Anti-Infective Agents / adverse effects
Anti-Inflammatory Agents / adverse effects,  therapeutic use
Antibodies, Monoclonal / adverse effects
Azathioprine / adverse effects,  therapeutic use
Female
Humans
Immunosuppressive Agents / adverse effects,  therapeutic use
Inflammatory Bowel Diseases / diagnosis,  drug therapy*
Pregnancy
Pregnancy Complications / diagnosis,  drug therapy*
Pregnancy Outcome*
Risk
Sulfasalazine / adverse effects
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Aminosalicylic Acids; 0/Anti-Infective Agents; 0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Immunosuppressive Agents; 0/infliximab; 446-86-6/Azathioprine; 50-44-2/6-Mercaptopurine; 599-79-1/Sulfasalazine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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