| Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse. | |
| | |
MedLine Citation:
|
PMID: 21315689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Our goal was to extend our understanding of the neural changes behind motor recovery with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse. We determined the extent of dopamine (DA) terminal changes using Western immunoblotting [striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH)] and alterations in the mean number of DA cells/section by immunohistochemistry and Nissl staining [TH-labeled cells and thionin-stained cells in the substantia nigra pars compacta (SN-PC)]. We measured recovery of gait performance and amount of spontaneous physical activity using the parallel rod activity chamber (PRAC). We hypothesized that the decrease in TH-labeled neurons in the SN-PC due to MPTP will be partially reversed by treadmill exercise, leading to recovery of motor behavior as measured by the PRAC. Following MPTP or vehicle administration, mice ran on the treadmill for 1h/day at 18cm/s, 5days/week. Results showed that treadmill exercise improves gait performance and increases physical activity while promoting increased protein expression of striatal DAT and TH. Exercise was effective for all mice; however, effects of early treadmill-based intervention appear to have an additional and unique benefit in mice who received MPTP. We are the first to show that, even following a nearly 50% decrease in the mean number of TH-labeled neurons/section in the SN-PC following MPTP, treadmill exercise leads to an increase of neurons in the SN-PC and improved motor behavior. |
| | |
Authors:
|
Beth A Smith; Natalie R S Goldberg; Charles K Meshul |
Related Documents
:
|
12703849 - Bilateral symmetry and the competitive standard attained in elite and sub-elite sport. 12930179 - Neuromuscular differences between endurance-trained, power-trained, and sedentary subje... 19528859 - Effect of timing of eccentric hamstring strengthening exercises during soccer training:... 17706459 - The reliability of physiological and performance measures during simulated team-sport r... 21168179 - Effects induced by exercise on lymphocyte β-adrenergic receptors and plasma catecholam... 20973829 - Previous-day hypohydration impairs skill performance in elite female field hockey players. 18391639 - Myocardial sarcoplasmic reticulum ca2+ atpase function is increased by aerobic interval... 3202799 - Toxicity assessment of hydrazine fuels. 18719669 - Effect of endurance exercise on hepatic lipid content, enzymes, and adiposity in men an... |
Publication Detail:
|
Type: Journal Article Date: 2011-03-21 |
Journal Detail:
|
Title: Brain research Volume: 1386 ISSN: 1872-6240 ISO Abbreviation: Brain Res. Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-04-08 Completed Date: 2012-03-12 Revised Date: 2012-10-09 |
Medline Journal Info:
|
Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 70-80 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
|
Balance Disorders Laboratory, Departments of Neurology and Behavioral Neuroscience, Oregon Health and Science University West Campus, 505 NW 185th Ave., Beaverton, OR 97006, USA. smitbeth@ohsu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blotting, Western Corpus Striatum / cytology, metabolism Exercise Test / methods* Exercise Therapy / methods* MPTP Poisoning / pathology*, physiopathology*, rehabilitation Male Mice Mice, Inbred C57BL Neural Pathways / cytology, metabolism Physical Conditioning, Animal / methods* Presynaptic Terminals / metabolism, ultrastructure Recovery of Function / physiology Substantia Nigra / cytology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
L30 NS071000/NS/NINDS NIH HHS; L30 NS071000-01/NS/NINDS NIH HHS; T32 AG023477-06/AG/NIA NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anti-diabetic and anti-adipogenic effects of a novel selective 11?-hydroxysteroid dehydrogenase type...
Next Document: Toll-like receptor 4 is involved in ischemic tolerance of postconditioning in hippocampus of Tree sh...