Document Detail

Effects of treadmill exercise on behavioral recovery and neural changes in the substantia nigra and striatum of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse.
MedLine Citation:
PMID:  21315689     Owner:  NLM     Status:  MEDLINE    
Our goal was to extend our understanding of the neural changes behind motor recovery with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mouse. We determined the extent of dopamine (DA) terminal changes using Western immunoblotting [striatal dopamine transporter (DAT) and tyrosine hydroxylase (TH)] and alterations in the mean number of DA cells/section by immunohistochemistry and Nissl staining [TH-labeled cells and thionin-stained cells in the substantia nigra pars compacta (SN-PC)]. We measured recovery of gait performance and amount of spontaneous physical activity using the parallel rod activity chamber (PRAC). We hypothesized that the decrease in TH-labeled neurons in the SN-PC due to MPTP will be partially reversed by treadmill exercise, leading to recovery of motor behavior as measured by the PRAC. Following MPTP or vehicle administration, mice ran on the treadmill for 1h/day at 18cm/s, 5days/week. Results showed that treadmill exercise improves gait performance and increases physical activity while promoting increased protein expression of striatal DAT and TH. Exercise was effective for all mice; however, effects of early treadmill-based intervention appear to have an additional and unique benefit in mice who received MPTP. We are the first to show that, even following a nearly 50% decrease in the mean number of TH-labeled neurons/section in the SN-PC following MPTP, treadmill exercise leads to an increase of neurons in the SN-PC and improved motor behavior.
Beth A Smith; Natalie R S Goldberg; Charles K Meshul
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Publication Detail:
Type:  Journal Article     Date:  2011-03-21
Journal Detail:
Title:  Brain research     Volume:  1386     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-08     Completed Date:  2012-03-12     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  70-80     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Blotting, Western
Corpus Striatum / cytology,  metabolism
Exercise Test / methods*
Exercise Therapy / methods*
MPTP Poisoning / pathology*,  physiopathology*,  rehabilitation
Mice, Inbred C57BL
Neural Pathways / cytology,  metabolism
Physical Conditioning, Animal / methods*
Presynaptic Terminals / metabolism,  ultrastructure
Recovery of Function / physiology
Substantia Nigra / cytology,  metabolism
Grant Support
L30 NS071000/NS/NINDS NIH HHS; L30 NS071000-01/NS/NINDS NIH HHS; T32 AG023477/AG/NIA NIH HHS; T32 AG023477-06/AG/NIA NIH HHS

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