Document Detail

Effects of transmyocardial laser revascularization by using a prototype pulsed CO2 laser on contractility and perfusion of chronically ischemic myocardium in a porcine model.
MedLine Citation:
PMID:  11110283     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to test a new prototype pulsed CO2 laser to be used for transmyocardial laser revascularization (TMR). We wanted to determine whether it can reduce thermal damage and mitigate induced ischemia with improvement in contractile reserve of the heart as evidenced by contrast echocardiography at rest and under dobutamine stress. TMR is an emerging surgical strategy for treatment of myocardial ischemia not amenable to conventional percutaneous or surgical revascularization. Eleven pigs underwent ameroid occluder placement at the origin of the circumflex coronary artery. Six weeks later, occlusion of the circumflex coronary artery was documented. TMR was then carried out on 10 pigs by using a prototype pulsed CO2 laser that delivered 8-12 joules in 1.5 ms with a spot size of 1 mm. Six weeks after TMR, the pigs were restudied. The animals developed significant ischemia after 6 weeks of ameroid occlusion, at rest (p = 0.01) and at peak stress (p = 0.004). Wall motion for the ischemic segments improved significantly 6 weeks after TMR at peak stress (p = 0.02). TMR results in an improvement in wall motion in our model of chronic ischemia and improves wall motion score index more during induced stress than at rest.
Y Wadia; A Khaki; M Kajitani; Y Mori; T Irvine; D Sahn; M Yessik; D Bahlman; A Furnary; K Gregory
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  46     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-01     Completed Date:  2001-04-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  786-91     Citation Subset:  IM    
Oregon Laser Center, St. Vincent's Hospital, Portland 97225, USA.
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MeSH Terms
Coronary Angiography
Disease Models, Animal
Laser Therapy / methods
Myocardial Contraction
Myocardial Ischemia / pathology,  physiopathology,  surgery*
Myocardial Reperfusion
Myocardial Revascularization / methods*

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