| Effects of transglucosidase on diabetes, cardiovascular risk factors, and hepatic biomarkers in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 22098444 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this 12-week, randomized, double-blind, placebo-controlled trial, the efficacy and safety of transglucosidase (TGD) were compared with placebo in patients with type 2 diabetes mellitus (T2DM). At 12 weeks, TGD 300 mg/d and TGD 900 mg/d significantly reduced HbA1c (0.18% and 0.21%) and insulin concentration (19.4 and 25.0 pmol/L), respectively, versus placebo. TGD 300 mg/d and TGD 900 mg/d also significantly reduced LDL-C (0.22 and 0.17 mmol/L, respectively). TGD 900 mg/d significantly reduced triglyceride by 0.24 mmol/L and diastolic blood pressure by 8 mmHg. Placebo was associated with a significant increase from baseline in BMI, ALT, and AST (0.17 kg/m(2) , 3, and 2 U/L, respectively), whereas TGD was not. TGD 300 mg/d significantly increased HMW adiponectin by 0.6 μg/mL. Adverse events did not differ significantly between the groups. TGD resulted in lowering of HbA1c and blood insulin level, and improvements in metabolic and cardiovascular risk factors in T2DM. |
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Authors:
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Makoto Sasaki; Kenro Imaeda; Naotsuka Okayama; Tatsuo Mizuno; Hiromi Kataoka; Takeshi Kamiya; Eiji Kubota; Naotaka Ogasawara; Yasushi Funaki; Mari Mizuno; Akihito Iidamd; Chiho Goto; Satoshi Koikeda; Kunio Kasugai; Takashi Joh |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-19 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Gastroenterology, Aichi Medical University School of Medicine Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences Nagoya Bunri University Amano Enzyme Inc. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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