Document Detail

Effects of transfusions in extremely low birth weight infants: a retrospective study.
MedLine Citation:
PMID:  19732577     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the risks and benefits associated with the transfusion of packed red blood cells (PRBCs) in extremely low birth weight (ELBW) infants. We hypothesized that when ELBW infants underwent transfusion with the University of Washington Neonatal Intensive Care Unit (NICU) 2006 guidelines, no clinical benefit would be discernible.
STUDY DESIGN: We conducted a retrospective chart review of all ELBW infants admitted to the NICU in 2006. Information on weight gain, apnea, heart rate, and respiratory support was collected for 2 days preceding, the day of, and 3 days after PRBC transfusion. The incidence, timing, and severity of complications of prematurity were documented.
RESULTS: Of the 60 ELBW infants admitted to the NICU in 2006, 78% received PRBC transfusions. Transfusions were not associated with improved weight gain, apnea, or ventilatory/oxygen needs. However, they were associated with increased risk of bronchopulmonary dysplasia, necrotizing enterocolitis, and diuretic use (P < .05). Transfusions correlated with phlebotomy losses, gestational age, and birth weight. No association was found between transfusions and sepsis, retinopathy of prematurity, or erythropoietin use.
CONCLUSIONS: When our 2006 PRBC transfusion guidelines were used, no identifiable clinical benefits were identified, but increased complications of prematurity were noted. New, more restrictive guidelines were developed as a result of this study.
Olga A Valieva; Thomas P Strandjord; Dennis E Mayock; Sandra E Juul
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  155     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-07     Completed Date:  2009-09-30     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  331-37.e1     Citation Subset:  AIM; IM    
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MeSH Terms
Academic Medical Centers / methods
Anemia, Neonatal / therapy*
Erythrocyte Transfusion*
Infant, Extremely Low Birth Weight*
Infant, Newborn
Infant, Premature
Intensive Care, Neonatal / methods
Practice Guidelines as Topic
Retrospective Studies
Risk Assessment
Treatment Outcome
Grant Support
1 UL1 RR025014-01/RR/NCRR NIH HHS; UL1 RR025014/RR/NCRR NIH HHS; UL1 RR025014-01/RR/NCRR NIH HHS

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