Document Detail

Effects of a transfusion with a blood substitute (Fluosol-DA, 20%) on cerebral circulation in the monkey.
MedLine Citation:
PMID:  6122175     Owner:  NLM     Status:  MEDLINE    
Local cerebral blood flow (lCBF) and electroencephalogram were monitored in six monkeys after a transfusion using a perfluorochemical suspension (Fluosol-DA, 20%) that has been manufactured as a blood substitute and is known to be synthetic, biologically inert, and nontoxic and to have a high capacity for carrying oxygen. The animals were mechanically ventilated, and blood gases were maintained at physiological levels. Fluosol-DA, 20% was administered either by an exchange transfusion of 20 ml/kg or by an infusion of 8 ml/kg followed by an exchange transfusion of 12 ml/kg. lCBF was measured using the hydrogen clearance technique. An equation was proposed to estimate the tissue-blood partition coefficient of hydrogen; this coefficient is considered to be dependent upon the amount of perfluorochemicals in the blood and was used to calculate lCBF. Systemic blood pressure, pulse rate, central venous pressure, electroencephalogram, and gas analysis of the blood from the femoral artery, the femoral vein, and the superior sagittal sinus showed little change throughout the experiment. lCBF was increased by 12% (p less than 0.005) after the infusion of Fluosol-DA, 20% of 8 ml/kg and by 31% (p less than 0.02) after the exchange transfusion. Hyperventilation reduced lCBF significantly (p less than 0.005), which implies that the reactivity of the cerebral blood vessels to hypocarbia was not impaired by the administration of FLuosol-DA, 20%. Both the results of this study and the physical properties of Fluosol-DA, 20% suggest that this blood substitute can safely be used for normal human brains and that it might also be effective for ischemic brains.
S Nagasawa; H Handa; Y Naruo; Y Oda; Y Yonekawa; Y Takebe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  3     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  1981  
Date Detail:
Created Date:  1982-06-14     Completed Date:  1982-06-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  237-50     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Blood Substitutes / pharmacology*
Brain Ischemia / therapy
Carbon Dioxide / analysis
Cerebrovascular Circulation / drug effects*
Drug Combinations / pharmacology
Fluorocarbons / pharmacology*
Oxygen / analysis
Pulse / drug effects
Reg. No./Substance:
0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 124-38-9/Carbon Dioxide; 75216-20-5/Fluosol-DA; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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