Document Detail


Effects of transforming growth factor-beta and formula feeding on systemic immune responses to dietary beta-lactoglobulin in allergy-prone rats.
MedLine Citation:
PMID:  16627876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Early nutritional events have the potential to affect health outcomes in later life including the development of allergy. Food allergy is usually the first manifestation of allergy. Breast-feeding has been associated with a protective effect against the development of allergy, but the evidence is contradictory and the mechanisms involved are not clear. We hypothesize that milk cytokines, such as transforming growth factor beta (TGF-beta), play a role in regulating immune responses to dietary antigens. Using a rat pup model of gastrostomy feeding, the immune response profile, at weaning and post-weaning, of allergy-prone Brown Norway rats fed formula supplementation with TGF-beta was assessed. We show that feeding formula to allergy-prone rat pups results in increased total IgE immunoglobulin, beta-lactoglobulin (BLG) IgG1 antibody, and mucosal mast cell activation, as measured by serum rat mast cell protease II (RMCPII) levels in the gut. Supplementation of formula with physiological levels of TGF-beta down-regulated the BLG IgG1 response as well as total IgE and mucosal mast cell activation. Supplementation of formula also resulted in an increase in Th1 cytokines, interleukin (IL)-18, IL-12p40, IL-12p35, and interferon gamma (IFN-gamma) and an increase in IL-10. In conclusion, TGF-beta supplementation of formula moved the immune response profile of allergy prone (Th2 type) rat pups toward a Th1 profile in the suckling period. Importantly, this immune profile persisted after weaning when TGF-beta was no longer present in the diet.
Authors:
Irmeli Penttila
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  59     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-06-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  650-5     Citation Subset:  IM    
Affiliation:
Child Health Research Institute, North Adelaide, South Australia, Australia 5006. irmeli.penttila@adelaide.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antibody Specificity
Chymases
Cytokines / genetics,  metabolism
Eosinophils / drug effects,  immunology,  pathology
Female
Ileum / drug effects,  immunology,  pathology
Immune Tolerance
Immunoglobulin E / blood
Immunoglobulin G / blood
Infant Formula / administration & dosage*
Lactoglobulins / immunology*
Mast Cells / drug effects,  enzymology,  immunology,  pathology
Milk / immunology
Milk Hypersensitivity / drug therapy*,  immunology*,  pathology
Pregnancy
RNA, Messenger / genetics,  metabolism
Rats
Rats, Inbred BN
Recombinant Proteins / administration & dosage
Serine Endopeptidases / metabolism
Spleen / immunology
Th1 Cells / drug effects,  immunology
Transforming Growth Factor beta / administration & dosage*
Chemical
Reg. No./Substance:
0/Cytokines; 0/Immunoglobulin G; 0/Lactoglobulins; 0/RNA, Messenger; 0/Recombinant Proteins; 0/Transforming Growth Factor beta; 37341-29-0/Immunoglobulin E; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.39/Chymases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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