| Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women. | |
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MedLine Citation:
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PMID: 22773769 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Menopause is associated with loss of collagen content in the skin and tendon as well as accumulation of non-contractile tissue in skeletal muscle. The relative role of hormones and physical activity on these changes is not known. Accordingly, in a randomized, controlled, crossover study we investigated effects of transdermal estrogen replacement therapy (ERT) on type I collagen synthesis in tendon and skeletal muscle in 11 postmenopausal women. Patches with estrogen (Evorel©) were placed on the skin above the patellar tendons and compared to no patch (control-period). On day two all subjects performed one-legged exercise, and thereafter the exercised leg (EX-leg) was compared to the non-exercised leg (Rest-leg). Microdialysis catheters were placed in front of the patellar tendons and in m. vastus lateralis of both legs at day 3 and 5. The collected dialysate was analyzed for aminoterminal propeptide of type I collagen (PINP), insulin-like growth factor I (IGF-I) and interleukin 6 (IL-6). Neither loading (Rest-leg vs. EX-leg) nor treatment (control vs. ERT) influenced peritendinous PINP, whereas combined exercise and ERT enhanced muscle PINP after 72 hrs (interaction between loading and treatment P=0.008). In neither skeletal muscle nor peritendionous fluid, IGF-I and IL-6 were influenced by treatment or exercise. In conclusion, ERT was associated with enhanced synthesis of type I collagen in the skeletal muscle in response to acute exercise. In perspective, this indicates that the availability of estrogen in postmenopausal women is important for repair of muscle damage or remodeling of the connective tissue within the skeletal muscle after exercise. |
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Authors:
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Jessica Pingel; Henning Langberg; Dorthe Skovgaard; Satu Koskinen; Allan Flyvbjerg; Jan F Frystyk; Michael Kjaer; Mette Hansen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-5 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Bispebjerg Hospital, and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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