Document Detail

Effects of transdermal estrogen on collagen turnover at rest and in response to exercise in postmenopausal women.
MedLine Citation:
PMID:  22773769     Owner:  NLM     Status:  MEDLINE    
Menopause is associated with loss of collagen content in the skin and tendon as well as accumulation of noncontractile tissue in skeletal muscle. The relative role of hormones and physical activity on these changes is not known. Accordingly, in a randomized, controlled, crossover study we investigated effects of transdermal estrogen replacement therapy (ERT) on type I collagen synthesis in tendon and skeletal muscle in 11 postmenopausal women. Patches with estrogen (Evorel) were placed on the skin above the patellar tendons and compared with no patch (control period). On day 2 all subjects performed one-legged exercise, and thereafter the exercised leg (EX leg) was compared with the nonexercised leg (Rest leg). Microdialysis catheters were placed in front of the patellar tendons and in the vastus lateralis muscle of both legs at days 3 and 5. The collected dialysate was analyzed for procollagen type I NH(2)-terminal propeptide (PINP), insulin-like growth factor I (IGF-I), and interleukin-6 (IL-6). Neither loading (Rest leg vs. EX leg) nor treatment (control vs. ERT) influenced peritendinous PINP, whereas combined exercise and ERT enhanced muscle PINP after 72 h (interaction between loading and treatment P = 0.008). In neither skeletal muscle nor peritendinous fluid were IGF-I and IL-6 influenced by treatment or exercise. In conclusion, ERT was associated with enhanced synthesis of type I collagen in the skeletal muscle in response to acute exercise. In perspective, this indicates that the availability of estrogen in postmenopausal women is important for repair of muscle damage or remodeling of the connective tissue within the skeletal muscle after exercise.
J Pingel; H Langberg; D Skovgård; S Koskinen; A Flyvbjerg; J Frystyk; M Kjær; M Hansen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-07-05
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-05-23     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1040-7     Citation Subset:  IM    
Institute of Sports Medicine, Department of Orthopedic Surgery M81, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23,Copenhagen, Denmark.
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MeSH Terms
Collagen Type I / biosynthesis,  metabolism*
Cross-Over Studies
Estradiol / blood,  metabolism
Estrogen Replacement Therapy / methods
Estrogens / administration & dosage*
Exercise / physiology*
Insulin-Like Growth Factor I / metabolism
Interleukin-6 / metabolism
Microdialysis / methods
Muscle, Skeletal / drug effects,  metabolism,  physiology
Patellar Ligament / drug effects,  metabolism,  physiology
Peptide Fragments / metabolism
Postmenopause / drug effects*,  metabolism,  physiology*
Procollagen / metabolism
Quadriceps Muscle / drug effects,  metabolism,  physiology
Rest / physiology*
Skin / metabolism
Transdermal Patch
Reg. No./Substance:
0/Collagen Type I; 0/Estrogens; 0/IL6 protein, human; 0/Interleukin-6; 0/Peptide Fragments; 0/Procollagen; 0/procollagen Type I N-terminal peptide; 50-28-2/Estradiol; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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