Document Detail


Effects of transdermal 17beta-estradiol on left ventricular anatomy and performance in hypertensive women.
MedLine Citation:
PMID:  10567179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To reduce cardiovascular complications, antihypertensive therapy should not only normalize blood pressure but also induce a regression of structural abnormalities, which are the expression of end-organ damage. We investigated the effects of transdermal 17beta-estradiol, combined with standard antihypertensive therapy, on the modification of left ventricular anatomy and systolic performance in hypertensive postmenopausal women. In a randomized, double-blind, placebo-controlled study, we enrolled 169 postmenopausal women with mild or moderate hypertension. Eighty-six patients (group 1) received transdermal 17beta-estradiol (50 microg/d) and norethisterone acetate (2.5 mg/d, orally), and 83 patients (group 2) received placebo. At baseline, all women underwent M-mode and 2-D echocardiogram, which was repeated after 6, 12, and 18 months of follow-up. After 18 months of treatment, we observed a significant decrease in left ventricular diastolic septal and posterior wall thickness and mass in both groups. Furthermore, after 18 months, left ventricular mass was significantly less than in the estrogen-treated group. No significant modifications were observed in left ventricular systolic and diastolic dimensions or in systolic performance, as expressed by left ventricular fractional shortening. In conclusion, transdermal 17beta-estradiol, which is associated with antihypertensive therapy, may contribute in the reduction of left ventricular mass in hypertensive postmenopausal women.
Authors:
M G Modena; N Muia; P Aveta; R Molinari; R Rossi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  34     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-10     Completed Date:  1999-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1041-6     Citation Subset:  IM    
Affiliation:
Institute of Cardiology II, Department of Internal Medicine, University of Modena, Italy. modena.m@policlinico.mo.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Double-Blind Method
Echocardiography
Estradiol / administration & dosage*
Estrogen Replacement Therapy*
Female
Humans
Hypertension / drug therapy*
Hypertrophy, Left Ventricular / prevention & control*
Middle Aged
Postmenopause
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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