| Effects of transdermal 17beta-estradiol on left ventricular anatomy and performance in hypertensive women. | |
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MedLine Citation:
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PMID: 10567179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To reduce cardiovascular complications, antihypertensive therapy should not only normalize blood pressure but also induce a regression of structural abnormalities, which are the expression of end-organ damage. We investigated the effects of transdermal 17beta-estradiol, combined with standard antihypertensive therapy, on the modification of left ventricular anatomy and systolic performance in hypertensive postmenopausal women. In a randomized, double-blind, placebo-controlled study, we enrolled 169 postmenopausal women with mild or moderate hypertension. Eighty-six patients (group 1) received transdermal 17beta-estradiol (50 microg/d) and norethisterone acetate (2.5 mg/d, orally), and 83 patients (group 2) received placebo. At baseline, all women underwent M-mode and 2-D echocardiogram, which was repeated after 6, 12, and 18 months of follow-up. After 18 months of treatment, we observed a significant decrease in left ventricular diastolic septal and posterior wall thickness and mass in both groups. Furthermore, after 18 months, left ventricular mass was significantly less than in the estrogen-treated group. No significant modifications were observed in left ventricular systolic and diastolic dimensions or in systolic performance, as expressed by left ventricular fractional shortening. In conclusion, transdermal 17beta-estradiol, which is associated with antihypertensive therapy, may contribute in the reduction of left ventricular mass in hypertensive postmenopausal women. |
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Authors:
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M G Modena; N Muia; P Aveta; R Molinari; R Rossi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 34 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 1999 Nov |
Date Detail:
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Created Date: 1999-12-10 Completed Date: 1999-12-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1041-6 Citation Subset: IM |
Affiliation:
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Institute of Cardiology II, Department of Internal Medicine, University of Modena, Italy. modena.m@policlinico.mo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Double-Blind Method Echocardiography Estradiol / administration & dosage* Estrogen Replacement Therapy* Female Humans Hypertension / drug therapy* Hypertrophy, Left Ventricular / prevention & control* Middle Aged Postmenopause Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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